Hepatitis Medicine

Ledifos (Ledipasvir & Sofosbuvir)

Brand name: Ledifos 

Active Ingeridents(Generic Name) : Ledipasvir & Sofosbuvir

Company Name: Hetero

Package: 28 tablets/bottle

Strength : Ledipasvir 90mg & Sofosbuvir 400mg

Indication:

Treating chronic hepatitis C virus (HCV) infection in certain patients.

Ledipasvir and sofosbuvir is a combination of 2 hepatitis C virus (HCV) antiviral agents. It reduces the amount of HCV in the body by preventing the spread of the HCV within the body.

Mechanism of action:

Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion. Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication. The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.

Dosage and Administration:

Ledipasvir-sofosbuvir (90 mg/400 mg) is a fixed-dose combination tablet . The recommended dosage is one tablet once daily, with or without food.

Side effects:

The following are the Common side effects

· fatigue

nausea
headache
diarrhea

· insomnia

Precaution:

· Tell your doctor or dentist that you take ledipasvir and sofosbuvir before you receive any medical or dental care, emergency care, or surgery.

· Do not share needles, injection supplies, or items like toothbrushes or razors. Talk with your health care provider about ways to prevent the spread of HCV to others.

Store: ledipasvir & Sofosbuvir  room temperature away from moisture and heat 

Natdac (Daclatasvir )

Brand name: Natdac

Active Ingeridents(Generic Name) : Daclatasvir

Company Name: Natco

Package: 28 Tablets/Bottle

Strength : 60 mg

Indication:

Daclatasvir is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Daclatasvir should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin). These medications together reduce the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.

Mechanism of action:

The dimeric symmetry of these compounds suggests that they act on a dimer of NS5A, which is also consistent with the presence of dimers in crystals of NS5A domain 1 from genotype 1b. Genotype 1a HCV is less potently affected by these compounds and resistance mutations have a greater effect than in the 1b genotypes. We have obtained crystals of domain 1 of the important 1a NS5A homologue and intriguingly, our X-ray crystal structure reveals two new dimeric forms of this domain. Furthermore, the high solvent content (75%) makes it ideal for ligand-soaking. Daclatasvir (DCV) shows twofold symmetry suggesting NS5A dimers may be of physiological importance and serve as potential binding sites for DCV. These dimers also allow for new conformations of a NS5A expansive network which could explain its operation on the membranous web. Additionally, sulfates bound in the crystal structure may provide evidence for the previously proposed RNA binding groove, or explain regulation of NS5A domain 2 and 3 function and phosphorylation.

Dosage and Administration:

Take daclatasvir exactly as your healthcare provider tells you to.

· Do not change your dose unless your healthcare provider tells you to.

· Do not stop taking daclatasvir without first talking with your healthcare provider.

· Take daclatasvir 1 time each day with or without food.

The recommended usage of daclatasvir to treat chronic hepatitis C virus is 60 mg taken orally once daily with or without food in combination with sofosbuvir. The recommended treatment duration is 12 weeks.

Side effects:

Tiredness, headache, nausea, or diarrhea may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Precaution: Before taking daclatasvir, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Store:. Daclatasvirroom temperature away from moisture and heat.

We are operating as the successful supplier and exporter of Cimivir. The offered product is effective in treating myelodysplastic syndrome. This drug has been made from high quality of material and is pure in composition. It is administered intravenously for fast recovery. Our product range is in compliance with the pharmaceutical standards.

Features:

• Given intravenously
• Used for treating myelodysplastic syndrome
• Accurate in composition

We are operating as the successful supplier and exporter of Dacihep Daclatasvir. The offered product is effective in treating myelodysplastic syndrome. This drug has been made from high quality of material and is pure in composition. It is administered intravenously for fast recovery. Our product range is in compliance with the pharmaceutical standards.

Features:

• Given intravenously
• Used for treating myelodysplastic syndrome
• Accurate in composition

Dalsiclear (Daclatasvir )

Brand name: Dalsiclear

Active Ingeridents(Generic Name) : Daclatasvir

Company Name: Abbott

Package: 28 Tablets/Bottle

Strength : 60 mg

Indication:

Daclatasvir is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Daclatasvir should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin). These medications together reduce the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.

Mechanism of action:

The dimeric symmetry of these compounds suggests that they act on a dimer of NS5A, which is also consistent with the presence of dimers in crystals of NS5A domain 1 from genotype 1b. Genotype 1a HCV is less potently affected by these compounds and resistance mutations have a greater effect than in the 1b genotypes. We have obtained crystals of domain 1 of the important 1a NS5A homologue and intriguingly, our X-ray crystal structure reveals two new dimeric forms of this domain. Furthermore, the high solvent content (75%) makes it ideal for ligand-soaking. Daclatasvir (DCV) shows twofold symmetry suggesting NS5A dimers may be of physiological importance and serve as potential binding sites for DCV. These dimers also allow for new conformations of a NS5A expansive network which could explain its operation on the membranous web. Additionally, sulfates bound in the crystal structure may provide evidence for the previously proposed RNA binding groove, or explain regulation of NS5A domain 2 and 3 function and phosphorylation.

Dosage and Administration:

Take daclatasvir exactly as your healthcare provider tells you to.

· Do not change your dose unless your healthcare provider tells you to.

· Do not stop taking daclatasvir without first talking with your healthcare provider.

· Take daclatasvir 1 time each day with or without food.

The recommended usage of daclatasvir to treat chronic hepatitis C virus is 60 mg taken orally once daily with or without food in combination with sofosbuvir. The recommended treatment duration is 12 weeks.

Side effects:

Tiredness, headache, nausea, or diarrhea may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Precaution: Before taking daclatasvir, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Store:. Daclatasvirroom temperature away from moisture and heat.

Drug Name:- Entecavir Medicines

Strength:- 400mg

Packing:- Pack of 28 Tablet

Uses:- Entecavir Medicines containing the active ingredient sofosbuvir is a nucleotide polymerase inhibitor type of antiviral medication used to treat Hepatitis C. Entecavir Medicinesmust be used in combination with other antiviral medicines to reduce the amount of hepatitis C virus (HCV) in the body to help the liver recover. Chronic hepatitis C infections can cause serious liver problems such as liver cancer or cirrhosis (scarring). Patients with HIV or liver cancer and are going to have a liver transplant may also use the drug to decrease the risk of reinfection after the transplant.

Side Effects :- Nausea, Diarrhea, Headaches, Loss of appetite, Lower back or side pain, Insomnia,Fever.

• Minimum Order Quantity: 3 Bottle(s)

Composition FOR ENTEHEP Entecavir(0.5 mg)

It is better to take Entehep 0.5 mg tablet empty stomach (1 hour before food or 2 hours after food).

Feature:

• Salt Information For Entehep
• Entecavir(0.5 Mg)
• Uses Entehep 0.5 mg tablet is used in the treatment of HIV infection and chronic hepatitis B

Hepcdac (Daclatasvir )

Brand name: Hepcdac

Active Ingeridents(Generic Name) : Daclatasvir

Company Name: Cipla

Package: 28 Tablets/Bottle

Strength : 60 mg

Indication:

Daclatasvir is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Daclatasvir should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin). These medications together reduce the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.

Mechanism of action:

The dimeric symmetry of these compounds suggests that they act on a dimer of NS5A, which is also consistent with the presence of dimers in crystals of NS5A domain 1 from genotype 1b. Genotype 1a HCV is less potently affected by these compounds and resistance mutations have a greater effect than in the 1b genotypes. We have obtained crystals of domain 1 of the important 1a NS5A homologue and intriguingly, our X-ray crystal structure reveals two new dimeric forms of this domain. Furthermore, the high solvent content (75%) makes it ideal for ligand-soaking. Daclatasvir (DCV) shows twofold symmetry suggesting NS5A dimers may be of physiological importance and serve as potential binding sites for DCV. These dimers also allow for new conformations of a NS5A expansive network which could explain its operation on the membranous web. Additionally, sulfates bound in the crystal structure may provide evidence for the previously proposed RNA binding groove, or explain regulation of NS5A domain 2 and 3 function and phosphorylation. 

Dosage and Administration:

Take daclatasvir exactly as your healthcare provider tells you to.

· Do not change your dose unless your healthcare provider tells you to.

· Do not stop taking daclatasvir without first talking with your healthcare provider.

· Take daclatasvir 1 time each day with or without food.

The recommended usage of daclatasvir to treat chronic hepatitis C virus is 60 mg taken orally once daily with or without food in combination with sofosbuvir. The recommended treatment duration is 12 weeks.

Side effects:

Tiredness, headache, nausea, or diarrhea may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Precaution: Before taking daclatasvir, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Store:. Daclatasvir room temperature away from moisture and heat. 

We are operating as the successful supplier and exporter of Hepcvir. The offered product is effective in treating myelodysplastic syndrome. This drug has been made from high quality of material and is pure in composition. It is administered intravenously for fast recovery. Our product range is in compliance with the pharmaceutical standards.

Features:

• Given intravenously
• Used for treating myelodysplastic syndrome
• Accurate in composition

Ledihep (Ledipasvir & Sofosbuvir)

• Brand name: Ledihep
• Active Ingeridents(Generic Name) : Ledipasvir & Sofosbuvir
• Company Name: Zydus Heptiza
• Package: 28 tablets/bottle
• Strength : Ledipasvir 90mg & Sofosbuvir 400mg

Indication:

Treating chronic hepatitis C virus (HCV) infection in certain patients.

Ledipasvir and sofosbuvir is a combination of 2 hepatitis C virus (HCV) antiviral agents. It reduces the amount of HCV in the body by preventing the spread of the HCV within the body.

Mechanism of action:

Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion. Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication. The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.

Dosage and Administration:

Ledipasvir-sofosbuvir (90 mg/400 mg) is a fixed-dose combination tablet . The recommended dosage is one tablet once daily, with or without food.

Side effects:

The following are the Common side effects

· fatigue

nausea
headache
diarrhea

· insomnia

Precaution:

· Tell your doctor or dentist that you take ledipasvir and sofosbuvir before you receive any medical or dental care, emergency care, or surgery.

· Do not share needles, injection supplies, or items like toothbrushes or razors. Talk with your health care provider about ways to prevent the spread of HCV to others.

Store: ledipasvir & Sofosbuvir room temperature away from moisture and heat

Myhep LVIR (Ledipasvir & Sofosbuvir)

Brand name: Myhep LVIR

Active Ingeridents(Generic Name) : Ledipasvir & Sofosbuvir

Company Name: Mylan

Package: 28 tablets/bottle

Strength : Ledipasvir 90mg & Sofosbuvir 400mg

Indication:

Treating chronic hepatitis C virus (HCV) infection in certain patients.

Ledipasvir and sofosbuvir is a combination of 2 hepatitis C virus (HCV) antiviral agents. It reduces the amount of HCV in the body by preventing the spread of the HCV within the body.

Mechanism of action:

Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion. Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication. The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.

Dosage and Administration:

Ledipasvir-sofosbuvir (90 mg/400 mg) is a fixed-dose combination tablet . The recommended dosage is one tablet once daily, with or without food.

Side effects:

The following are the Common side effects

· fatigue

nausea
headache
diarrhea

· insomnia

Precaution:

· Tell your doctor or dentist that you take ledipasvir and sofosbuvir before you receive any medical or dental care, emergency care, or surgery.

· Do not share needles, injection supplies, or items like toothbrushes or razors. Talk with your health care provider about ways to prevent the spread of HCV to others.

Store: ledipasvir & Sofosbuvir room temperature away from moisture and heat

 Novisof (Sofosbuvir )

Brand name: Novisof

Active Ingeridents(Generic Name) : Sofosbuvir

Company Name: Wockhardt

Package: Bottle(s)

Strength : 400mg

Indication:

It is used for the treatment of hepatitis Cvirus (HCV) infection. Compared to previous treatments, sofosbuvir-based regimens provide a higher cure rate, fewer side effects, and a two- to four-fold reduced duration of therapy. Sofosbuvir allows most patients to be treated successfully without the use of peginterferon,an injectable drug with severe side effects^. that is a key component of older drug combinations for the treatment of HCV.

Sofosbuvir is used for the treatment of chronic hepatitis C, genotypes 1, 2, 3, and 4, in combination with pegylated interferon and ribavirin, or with ribavirin alone. It is also used in combination with the viral NS5a inhibitor ledipasvir in an interferon-free combination for the treatment of genotype 1 hepatitis C infection. Sofosbuvir is also used in HCV patients with an HIV coinfection. The treatment is based on a number of clinical trials, for example the ELECTRON trial which showed that a dual interferon-free regimen of sofosbuvir plus ribavirin produced a 24-week post-treatment sustained virological response (SVR24) rate of 100% for previously untreated patients with HCV genotypes 2 or 3.

Mechanism of action:

Sofosbuvir contains oral nucleotide analog inhibitor of the hepatitis C virus (HCV) polymerase. The drug is a direct-acting antiviral agent and interferes straight with the HCV lifecycle, restraining the viral replication. It can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator. The drug is available for oral use in the form of 400mg tablets.

Dosage and Administration:

The recommended daily dose of Sofosbuvir is 400mg tablet to be taken once daily with or without food. Sofosbuvir should be used in combination with Ribavirin or in combination with Pegylated Interferon and Ribavirin for the treatment of CHC (Chronic Hepatitis C) in adults. It is highly advisable to administer the drug under strict medical supervision and advice.

Side effects:

Adverse events associated with the use of Sofosbuvir in combination with Ribavirin may include, but are not limited to, the following

o Fatigue , headache

Adverse events associated with the use of Sofosbuvir in combination with Peginterferon Alfa and Ribavirin may include, but are not limited to, the following:

o fatigue,headache, nausea, insomnia, anemia

Precaution: Safety and efficacy have not been established in patients younger than 18 years. Consult WARNINGS section for additional precautions.

Store: Store at 25°C in a dry place.

Resof L (Ledipasvir & Sofosbuvir)

Brand name: Resof L

Active Ingeridents(Generic Name) : Ledipasvir & Sofosbuvir

Company Name: Dr.Reddy’s

Package: 28 tablets/bottle

Strength : Ledipasvir 90mg & Sofosbuvir 400mg

Indication:

Treating chronic hepatitis C virus (HCV) infection in certain patients.

Ledipasvir and sofosbuvir is a combination of 2 hepatitis C virus (HCV) antiviral agents. It reduces the amount of HCV in the body by preventing the spread of the HCV within the body.

Mechanism of action:

Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion. Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication. The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.

Dosage and Administration:

Ledipasvir-sofosbuvir (90 mg/400 mg) is a fixed-dose combination tablet . The recommended dosage is one tablet once daily, with or without food.

Side effects:

The following are the Common side effects

· fatigue

• nausea
• headache
• diarrhea

· insomnia

Precaution:

· Tell your doctor or dentist that you take ledipasvir and sofosbuvir before you receive any medical or dental care, emergency care, or surgery.

· Do not share needles, injection supplies, or items like toothbrushes or razors. Talk with your health care provider about ways to prevent the spread of HCV to others.

Store: ledipasvir & Sofosbuvir room temperature away from moisture and heat

Sofab (Sofosbuvir )

Brand name: Sofab

Active Ingeridents(Generic Name) : Sofosbuvir

Company Name: Ranbaxy

Package: 28 Tablets

Strength : 400mg

Indication:

It is used for the treatment of hepatitis Cvirus (HCV) infection. Compared to previous treatments, sofosbuvir-based regimens provide a higher cure rate, fewer side effects, and a two- to four-fold reduced duration of therapy. Sofosbuvir allows most patients to be treated successfully without the use of peginterferon,an injectable drug with severe side effects^. that is a key component of older drug combinations for the treatment of HCV.

Sofosbuvir is used for the treatment of chronic hepatitis C, genotypes 1, 2, 3, and 4, in combination with pegylated interferon and ribavirin, or with ribavirin alone. It is also used in combination with the viral NS5a inhibitor ledipasvir in an interferon-free combination for the treatment of genotype 1 hepatitis C infection. Sofosbuvir is also used in HCV patients with an HIV coinfection. The treatment is based on a number of clinical trials, for example the ELECTRON trial which showed that a dual interferon-free regimen of sofosbuvir plus ribavirin produced a 24-week post-treatment sustained virological response (SVR24) rate of 100% for previously untreated patients with HCV genotypes 2 or 3.

Mechanism of action:

Sofosbuvir contains oral nucleotide analog inhibitor of the hepatitis C virus (HCV) polymerase. The drug is a direct-acting antiviral agent and interferes straight with the HCV lifecycle, restraining the viral replication. It can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator. The drug is available for oral use in the form of 400mg tablets. 

Dosage and Administration:

The recommended daily dose of Sofosbuvir is 400mg tablet to be taken once daily with or without food. Sofosbuvir should be used in combination with Ribavirin or in combination with Pegylated Interferon and Ribavirin for the treatment of CHC (Chronic Hepatitis C) in adults. It is highly advisable to administer the drug under strict medical supervision and advice. 

Side effects:

Adverse events associated with the use of Sofosbuvir in combination with Ribavirin may include, but are not limited to, the following

o Fatigue , headache

Adverse events associated with the use of Sofosbuvir in combination with Peginterferon Alfa and Ribavirin may include, but are not limited to, the following:

o fatigue,headache, nausea, insomnia, anemia

Precaution: Safety and efficacy have not been established in patients younger than 18 years. Consult WARNINGS section for additional precautions. 

Store: Store at 25°C in a dry place. 

Sofocure (Sofosbuvir )

Brand name: Sofocure

Active Ingeridents(Generic Name) : Sofosbuvir

Company Name: Emcure

Package: 28 Tablets

Strength : 400mg

Indication:

It is used for the treatment of hepatitis Cvirus (HCV) infection. It has been marketed since 2013. Compared to previous treatments, sofosbuvir-based regimens provide a higher cure rate, fewer side effects, and a two- to four-fold reduced duration of therapy. Sofosbuvir allows most patients to be treated successfully without the use of peginterferon,an injectable drug with severe side effects^. that is a key component of older drug combinations for the treatment of HCV.

Sofosbuvir is used for the treatment of chronic hepatitis C, genotypes 1, 2, 3, and 4, in combination with pegylated interferon and ribavirin, or with ribavirin alone. It is also used in combination with the viral NS5a inhibitor ledipasvir in an interferon-free combination for the treatment of genotype 1 hepatitis C infection. Sofosbuvir is also used in HCV patients with an HIV coinfection. The treatment is based on a number of clinical trials, for example the ELECTRON trial which showed that a dual interferon-free regimen of sofosbuvir plus ribavirin produced a 24-week post-treatment sustained virological response (SVR24) rate of 100% for previously untreated patients with HCV genotypes 2 or 3.

Mechanism of action:

Sofosbuvir contains oral nucleotide analog inhibitor of the hepatitis C virus (HCV) polymerase. The drug is a direct-acting antiviral agent and interferes straight with the HCV lifecycle, restraining the viral replication. It can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator. The drug is available for oral use in the form of 400mg tablets.

Dosage and Administration:

The recommended daily dose of Sofosbuvir is 400mg tablet to be taken once daily with or without food. Sofosbuvir should be used in combination with Ribavirin or in combination with Pegylated Interferon and Ribavirin for the treatment of CHC (Chronic Hepatitis C) in adults. It is highly advisable to administer the drug under strict medical supervision and advice.

Side effects:

Adverse events associated with the use of Sofosbuvir in combination with Ribavirin may include, but are not limited to, the following

o Fatigue , headache

Adverse events associated with the use of Sofosbuvir in combination with Peginterferon Alfa and Ribavirin may include, but are not limited to, the following:

o fatigue,headache, nausea, insomnia, anemia

Precaution: Safety and efficacy have not been established in patients younger than 18 years. Consult WARNINGS section for additional precautions.

Store: Store at 25°C in a dry place.

Sofovir

• Brand name: Sofovir
• Active Ingredients(Generic Name) : Sofosbuvir
• Company Name: Hetero
• Package: 7 Tabs/bottle
• Strength : 400mg

It is used for the treatment of hepatitis Cvirus (HCV) infection. Compared to previous treatments, sofosbuvir-based regimens provide a higher cure rate, fewer side effects, and a two- to four-fold reduced duration of therapy. Sofosbuvir allows most patients to be treated successfully without the use of peginterferon.

Mechanism of action:

Sofosbuvir contains oral nucleotide analog inhibitor of the hepatitis C virus (HCV) polymerase. The drug is a direct-acting antiviral agent and interferes straight with the HCV lifecycle, restraining the viral replication. It can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator. The drug is available for oral use in the form of 400mg tablets.

Dosage and Administration:The recommended daily dose of Sofosbuvir is 400mg tablet to be taken once daily with or without food. Sofosbuvir should be used in combination with Ribavirin or in combination with Pegylated Interferon and Ribavirin for the treatment of CHC (Chronic Hepatitis C) in adults. It is highly advisable to administer the drug under strict medical supervision and advice.

Side effects:

Adverse events associated with the use of Sofosbuvir in combination with Ribavirin may include, but are not limited to, the following o Fatigue , headache

Adverse events associated with the use of Sofosbuvir in combination with Peginterferon Alfa and Ribavirin may include, but are not limited to, the following:o fatigue, headache, nausea, insomnia, anemia

 Precaution: Safety and efficacy have not been established in patients younger than 18 years. Consult WARNINGS section for additional precautions.

Store: Store at 25°C in a dry place.

Viroclear

• Brand name: Viroclear
• Active Ingeridents(Generic Name) : Sofosbuvir
• Company Name: Abbott
• Package: 28 tabs/bottle
• Strength : 400mg

Indication:

It is used for the treatment of hepatitis Cvirus (HCV) infection. Compared to previous treatments, sofosbuvir-based regimens provide a higher cure rate, fewer side effects, and a two- to four-fold reduced duration of therapy. Sofosbuvir allows most patients to be treated successfully without the use of peginterferon,an injectable drug with severe side effects^. that is a key component of older drug combinations for the treatment of HCV.

Mechanism of action:

Sofosbuvir contains oral nucleotide analog inhibitor of the hepatitis C virus (HCV) polymerase. The drug is a direct-acting antiviral agent and interferes straight with the HCV lifecycle, restraining the viral replication. It can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator. The drug is available for oral use in the form of 400mg tablets.

Dosage and Administration:

The recommended daily dose of Sofosbuvir is 400mg tablet to be taken once daily with or without food. Sofosbuvir should be used in combination with Ribavirin or in combination with Pegylated Interferon and Ribavirin for the treatment of CHC (Chronic Hepatitis C) in adults. It is highly advisable to administer the drug under strict medical supervision and advice.

Side effects:

Adverse events associated with the use of Sofosbuvir in combination with Ribavirin may include, but are not limited to, the following

o Fatigue , headache

Adverse events associated with the use of Sofosbuvir in combination with Peginterferon Alfa and Ribavirin may include, but are not limited to, the following:

o fatigue,headache, nausea, insomnia, anemia

Precaution: Safety and efficacy have not been established in patients younger than 18 years. Consult WARNINGS section for additional precautions.

Store: Store at 25°C in a dry place.

X-Vir (Entecavir) is used as an antiviral treatment for patients suffering from a chronic hepatitis B infection. It is classified as a nucleoside analog, and it works by stopping the spread of the virus. Because it can inhibit an enzyme called viral DNA polymerase, it is able to prevent the spread and proliferation of the virus. This can help to reduce the overall amount of the virus present in the body, while also helping to lessen damage to the liver.

X-Vir (Entecavir) is administered orally. It comes as either 0.5mg or 1mg strength tablets. Your physician will be responsible for deciding the right dosage. Adults treating hepatitis B who are deemed to be nucleoside therapy naive may be directed to take 0.5mg once per day. However, some patients may be directed to take 1mg per day (usually in cases of mutations of the virus that are resistance to lamivudine or otherwise difficult to treat). Patients must strictly comply with the instructions given by their physician.

The use of X-Vir (Entecavir) could cause side effects. Tell the physician providing medical care if this happens. Some possible examples are given here:

• Diarrhea
• Headaches
• Digestive discomfort
• Sleepy or fatigued feeling
• Nausea, possibly resulting in vomiting

Although the majority of side effects caused by this medicine are less serious in nature, there is a possibility that some patients will be affected by reactions which are significantly more serious. You must attend the hospital or see your physician straight away if you are affected by coldness, persistent vomiting, feeling weak or any other serious side effects not mentioned here.

Serious conditions including hepatomegaly and lactic acidosis are known to have occurred in some patients treated with X-Vir (Entecavir) for their condition. Discuss this with your physician before starting therapy.

This medication will not cure the infection, and you will need continuous medical treatment in order to manage your condition.

X-vir (Entecavir)

• Brand name: X-vir 
• Active Ingeridents(Generic Name) : Entecavir 
• Company Name: Natco
• Package: 30 Tablets
• Strength : 0.5mg

Indication: Entecavir is used to treat long-term hepatitis B infection. Hepatitis B is an infection of the liver caused by the hepatitis B virus. Long-term infection can cause liver damage, rarely liver cancer, and liver failure. Entecavir helps to decrease the amount of hepatitisB virus in your body. It is unknown if this medication lowers your chance of gettingliver cancer or liver damage. Entecavir is an antiviral that belongs to a class of drugs known as hepatitis B virus nucleoside reverse transcriptase inhibitors.

Mechanism of action:

Entecavir is mainly used to treat chronic hepatitis B infection in adults and children 2 years and older with active viral replication and evidence of active disease.It is also used to prevent HBV reinfection after liver transplant and to treat HIV patients infected with HBV. Entecavir is weakly active against HIV, however it is not recommended for use in HIV-HBV co-infected patients without a fully suppressive anti-HIV regimen as it may select for resistance to lamivudine and emtricitabine in HIV. 

Dosage and Administration:

· Take entecavir on an empty stomach, at least 2 hours after a meal and at least 2 hours before the next meal.

· Entecavir works best if it is taken at the same time each day.

· Continue to take entecavir even if you feel well. Do not miss any doses.

· If you miss a dose of entecavir, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Side effects:

Dizziness; headache; nausea; tiredness. 

Precaution:

An overdose entecavir Unlikely to threaten life, call an emergency room or a poison control center for advice if you suspect that a very large dose of entecavir has been ingested.

There are no restrictions on food, beverages, or activities while taking entecavir otherwise directed by your physician. 

Store:

Store entecavir in the original carton at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep entecavir out of the reach of children and away from pets.

Indication:

Velasof is an combination of velpatasvir 100mg+ Sofosbuvir 400mg. Velasof is a two-drug combination for the treatment of hepatitis C. It is administered as a single daily pill containing the viral NS5A inhibitor velpatasvir and sofosbuvir,a nucleotide inhibitor of the viral RNA polymerase. It is the first treatment, that works for all genotypic, and is taken entirely by mouth. A single tablet regimen is used for adults with genotype 1-6 chronic hepatitis C virus (HCV) infection with pangenotypic activity.

Dosage and Administration:

Take Velasof exactly as your healthcare provider tells you to.

• Patients without cirrhosis or with compensated cirrhosis (Child-Pugh A): velasof for 12 weeks.
• Patients with decompensated cirrhosis (Child-Pugh B or C): velasof.
• plus weight-based ribavirin with food for 12 weeks
• Weight-based ribavirin dose.
• Less than 75 kg: 1000 mg/day PO divided BID
• ≥75 kg: 1200 mg/day PO divided BID
• Ribavirin starting dose and on-treatment dosage should be modified based on hemoglobin and creatinine clearance
• Dose modification:Severe renal impairment (eGFR less than 30mL/min/1.73 m²) or ESRD: No dosage recommendation can be give owing to higher exposures (up to 20-fold) of the predominant sofosbuvir metabolite