AntiCancer Medicine

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Lanolimus 0.5mg Tablet is an immunosuppressant medication containing the active constituent everolimus. It is used to prevent the body’s immune system from rejecting a transplanted kidney, liver, or heart. It is used in combination with other medicines. Talk to your doctor if you have had recent major surgery, unhealed wound following surgery, kidney disorders, liver problems, allergic conditions, or respiratory symptoms (wheezing, difficulty breathing, coughing) before taking this medicine. 

This medicine is not recommended for adolescents and children under the age of 18. You need to tell your doctor about all the medications you are taking recently before taking Lanolimus 0.5mg Tablet. You must limit your exposure to sunlight and UV light by wearing protective clothing and applying sunscreen frequently, as this medicine may increase the risk of developing cancers. Avoid taking grapefruit juice or grapefruit while taking this medicine. 

If you are a man wanting to father a child, you should discuss the treatment with your physician, as taking Lanolimus 0.5mg Tablet may reduce sperm production in men. Inform your physician if you have been told that you have an intolerance to some sugars, as this medicine contains lactose.

Uses of Lanolimus 0.5mg Tablet:

• Prevents rejection of transplanted organs

How Lanolimus 0.5mg Tablet works:

Lanolimus 0.5mg Tablet inhibits the protein interleukin (IL-2 and IL-5). This inhibits the activation and multiplication of B and T lymphocytes (cells that play a central role in the body’s immune system), thereby suppressing the immune function and preventing transplant rejection.

Interactions with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More information:

• Keep Lanolimus 0.5mg Tablet out of sight and reach of children.
• Store below 30°C.

How to use Lanolimus 0.5mg Tablet:

Always take Lanolimus 0.5mg Tablet exactly as your doctor has told you. Do not crush or chew the tablets. In order to keep constant levels in your body, you should always take Lanolimus 0.5mg Tablet in the same way, either always with food or always on an empty stomach. Avoid taking grapefruit juice or grapefruit while taking this medicine.

Safety advice:

Pregnancy:

Use effective birth control during the treatment and for at least 8 weeks after stopping the treatment. Tell your doctor if you are pregnant or planning to get pregnant before taking Lanolimus 0.5mg Tablet. It will be given to you if clearly needed.

Breastfeeding:

You should not breastfeed while taking this medicine. Inform your doctor if you are breastfeeding before taking Lanolimus 0.5mg Tablet.

Liver:

You need to tell your doctor if you have any liver disorders before taking Lanolimus 0.5mg Tablet. Your doctor may modify the dose according to your liver condition.

Kidney:

You need to tell your doctor if you have any kidney disorders before taking Lanolimus 0.5mg Tablet. Your doctor will examine your kidney function before treatment.

Others:

• Limit your exposure to sunlight and UV light. Wear protective clothing and apply sunscreen frequently.
• Talk to your doctor if you have any intolerance to sugars, have had a recent major surgery or unhealed wound following surgery.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Additional Information:

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Mylimus 1.0mg Capsule is an immunosuppressant medicine containing the active constituent tacrolimus. It helps prevent organ rejection in people who have had liver, heart, or kidney transplants. Following an organ transplant, our body’s immune system will try to reject the new organ. This medication controls the body’s immune response to accept the transplanted organ.

You need to inform your physician if you have any liver disorders, diarrhea, severe abdominal pain, heart disorders, kidney disorders, if you are allergic to peanuts or soya, or if you are planning to receive any vaccinations before taking Mylimus 1.0mg Capsule. Limit exposure to the sun while taking this medication. Use sunscreen with high SPF (sun protection factor) and wear protective clothing when you go outside.

Make sure you tell your physician of all the medicines, including supplements and herbal medicines, you are taking before you start treatment with Mylimus 1.0mg Capsule. Avoid eating grapefruits and drinking grapefruit juice while taking this medication. You need to tell your doctor if you have any intolerance to some sugars as this medication contains lactose.

Uses of Mylimus 1.0mg Capsule:

• Prevents organ rejection, followed by an organ transplant

How Mylimus 1.0mg Capsule works:

Mylimus 1.0mg Capsule decreases the activity of your body’s immune system and prevents it from attacking the transplanted organ.

Interactions with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More information:

• Keep out of sight and reach of children.
• Store at 15°C to 30ºC in a dry and dark place.

How to use Mylimus 1.0mg Capsule:

Always take Mylimus 1.0mg Capsule exactly as your physician has told you to. This medication is usually taken on an empty stomach or at least one hour before or 2 to 3 hours after a meal. Swallow the capsules whole with water. Avoid eating grapefruits and drinking grapefruit juice while taking this medication.

Safety advice:

Pregnancy:

This medication may cause harm to the unborn baby. You need to inform your physician if you are pregnant or planning to get pregnant before taking Mylimus 1.0mg Capsule.

.

Breast Feeding:

Do not breastfeed while taking Mylimus 1.0mg Capsule as this medicine can pass through the breast milk. You need to inform the physician if you are breastfeeding before taking this medication.

Liver: 

You need to inform your physician if you have any liver diseases before taking Mylimus 1.0mg Capsule, as this medication should be used with caution in liver disease patients.

Kidney:

You need to inform your physician if you have any kidney diseases before taking Mylimus 1.0mg Capsule, as this medication should be used with caution in liver disease patients.

Driving:

Mylimus 1.0mg Capsule may cause sleepiness or dizziness. Avoid driving if you are unwell.

Alcohol:

It is advisable to consult your doctor before consuming alcohol while taking a Mylimus 1.0mg Capsule.

Others:

Talk to your doctor if:

• You are planning to receive any vaccines.
• You have an intolerance to some sugars.
• You are allergic to soy or peanuts.
• You have heart problems, abdominal pain or diarrhea.

Side effects are unwanted symptoms caused by medicines. All medicines cause side effects; although not everyone gets them.

Severe:

• Abdominal pain along with or without chills, fever, nausea, or vomiting
• Blurred vision
• Insufficient function of the transplanted organ

Additional Information:

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It is used in the treatment of intermediate or high-risk myelofibrosis, a type of myeloproliferative disorder that affects the bone marrow, and for polycythemia vera (PCV) when there has been an inadequate response to or intolerance of hydroxyurea.

Mechanism of action:

Capnat Medicines is a Janus kinase inhibitor with selectivity for subtypes JAK1 and JAK2 of this enzyme. Ruxolitinib inhibits dysregulated JAK signaling associated with myelofibrosis. JAK1 and JAK2 recruit signal transducers and activators of transcription (STATs) to cytokine receptors leading to modulation of gene expression.

Dosage and Administration:

Capnat Medicines is a pill, taken by mouth, with or without food. Take ruxolitinib exactly as prescribed, even if you are feeling better. Swallow ruxolitinib tablets whole. Do not chew, crush or break.

Side Effects:

Side effects include thrombocytopenia (low blood platelet count), anemia (low red blood cell count) and neutropenia; risk of infection; symptom exacerbation if the medication is interrupted or discontinued; and non-melanoma skin cancer.

Immunologic side effects have included herpes zoster (shingles) and case reports of opportunistic infections. Metabolic side effects have included weight gain. Laboratory abnormalities have included alanine transaminase (ALT) abnormalities, aspartate transaminase (AST) abnormalities, and mildly elevated cholesterol levels.

Precaution:

• Capnat Medicinesmay interact with many types of medications . Before starting ruxolitinib treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
• Do not receive any kind of immunization or vaccination without your doctor''s approval while taking ruxolitinib.
• Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category C (use in pregnancy only when benefit to the mother outweighs risk to the fetus).

Store: Store Capnat Medicines at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep abiraterone acetate out of the reach of children and away from pets.

• Minimum Order Quantity: 1 14 Tabs in strip

Additional Information:

Approx. Rs 10,500 / VialGet Latest Price

Brand Name: MABALL

Generic Name: Rituximab

Company: Hetero

Strength: 500mg/50ml

Indications:

Rituximab is used to treat certain types of cancer (such as non-Hodgkin's lymphoma, chronic lymphocytic leukemia). It works by slowing or stopping the growth of cancer cells.       

How to use Rituximab        

Read the Medication Guide provided by your pharmacist before you start using rituximab and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Side Effects

Nausea, vomiting, headache, dizziness, joint/muscle pain, weakness, or flushing may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Precautions

Before using rituximab, tell your doctor or pharmacist if you are allergic to it; or to mouse protein; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Additional Information:

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Brand name: Tacrograf 

Active Ingeridents(Generic Name) : Tacrolimus

Company Name: Biocon 

Package: 10 caps in strip

Strength : 0.5mg

Indication: indicated for organ transplant rejection prophylaxis. Patients are prescribed this medicine after an organ transplant, so as to help prevent the immune system from attacking the organ and to stop the body rejecting the transplant.

Mechanism of action: Tacrolimus is a macrolide calcineurin inhibitor. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to activate calcineurin. Calcineurin then dephosphorylates the transcription factor nuclear factor of activated T-cells (NF-AT), which moves to the nucleus of the T-cell and increases the activity of genes coding for IL-2 and related cytokines. Tacrolimus prevents the dephosphorylation of NF-AT. In detail, Tacrolimus reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin, thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription. Although this activity is similar to that of ciclosporin, the incidence of acute rejection is reduced by tacrolimus use over ciclosporin. Although short-term immunosuppression concerning patient and graft survival is found to be similar between the two drugs, tacrolimus results in a more favorable lipid profile, and this may have important long-term implications given the prognostic influence of rejection on graft survival. 

Dosage and Administration: Oral tacrolimus is taken twice daily. Starting doses range between 0.075 mg/kg/day to 0.2 mg/kg/day. Doses vary widely and are based on tests that measure the amount of tacrolimus in the blood. Taking tacrolimus with food can reduce some of the abdominal pain that can occur with this medicine; however, food can reduce the amount of tacrolimus that is absorbed. This is especially true with fatty foods. Capsules should be taken consistently with or without food in order to avoid major swings in blood levels. Grapefruit juice increases blood levels of tacrolimus and should be avoided. The injection is only used for patients who cannot tolerate tacrolimus capsules. 

Side effects:

Tacrolimus is associated with many and various side effects. These include:

· baldness,anemia,loss of appetite,diarrhea,high concentrations of potassium in the blood,high blood pressure, nausea, vomiting, ,tingling sensation in the extremities, itching, tremor, fever, headache, rash, high blood sugar concentrations, and, abdominal pain.

Precaution:

An overdose Tacrolimus Unlikely to threaten life, call an emergency room or a poison control center for advice if you suspect that a very large dose of Tacrolimus has been ingested.

There are no restrictions on food, beverages, or activities while taking Tacrolimus otherwise directed by your physician. 

Store: Tacrolimus is usually handled and stored by a health care provider. If you are using tacrolimus at home, store tacrolimus as directed by your pharmacist or health care provider. Keep tacrolimus out of the reach of children and away from pets.

Approx. Rs 4,250 / PieceGet Latest Price

We are operating as the successful supplier and exporter of Consuim Injection. The offered product is effective in treating myelodysplastic syndrome. This drug has been made from high quality of material and is pure in composition. It is administered intravenously for fast recovery. Our product range is in compliance with the pharmaceutical standards.

Features:

• Given intravenously
• Used for treating myelodysplastic syndrome
• Accurate in composition

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Graftide M 500mg Tablet contains the active ingredient Mycophenolate mofetil. It is an immunosuppressant used to prevent and treat organ rejection in patients receiving allogenic, kidney, heart, or liver transplants. It is indicated along with other immunosuppressants to avoid the rejection of the transplanted organ. 

Inform your doctor immediately if there are any signs of fever, sore throat, bleeding, or stomach ulcer. Talk to your doctor before getting vaccinated using live vaccines. Men using Graftide M 500mg Tablet must not donate sperm during the treatment and must avoid it for at least 90 days after the end of the treatment

Immunosuppressants increase the risk of skin cancer. Limit your exposure to the sun, wear protective clothing and use a sunscreen with high SPF. Mycophenolate Mofetil can cause defects in the foetus and miscarriages; hence do not start treatment with this medication without informing your doctor.

Effective contraception must be followed before, during, and till six months after the end of treatment with Graftide M 500mg Tablet. Diarrhoea, constipation, nausea, vomiting, stomach pain, dizziness, and headache are some common side effects of this medication.

Uses of Graftide M 500mg Tablet:

• Prevention of organ rejection after organ transplantation (liver, kidney or heart).
• To prolong the survival of the transplanted organ.
• Prophylaxis and treatment of acute and chronic Graft versus Host disease in hematopoietic stem cell transplant patients.

How Graftide M 500mg Tablet Works:

Graftide M 500mg Tablet converts into its active form known as Mycophenolic acid and suppresses the production of T- and B-cells. This reduces the cell-mediated immune responses and antibody formation. 

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

How to store Graftide M 500mg Tablet:

Store Graftide M 500mg Tablet protected from light at a temperature not exceeding 30°C.

How to use Graftide M 500mg Tablet:

Use Graftide M 500mg Tablet as directed by your doctor. Your doctor will prescribe a dose depending on the organ transplant performed (heart, liver, or kidney). Avoid direct contact of the medicine with the skin and mucous membranes. If contact occurs, rinse with soap water and eyes with plain water.

Safety Advice:

Pregnancy:

Graftide M 500mg Tablet is unsafe to use during pregnancy as it can harm the foetus and cause birth defects when administered to pregnant women. Take this medication only if prescribed by your doctor.

Breast feeding: 

Do not take Graftide M 500mg Tablet as it is unsafe to use during breastfeeding since small amounts of drug pass through the breast milk. 

Liver: 

Inform your doctor in case you have any liver diseases.

kidney: 

Inform your doctor in case you have any kidney diseases.

Alcohol:

Consult your doctor to know whether it is safe to consume alcohol while using Graftide M 500mg Tablet.

Driving: 

Avoid driving or operating machinery during the treatment with Graftide M 500mg Tablet in case you experience side effects.

Others:

• Do not donate blood for at least 6 weeks after completion of the treatment.
• Inform your physician if you have stomach ulcers.
• Use an effective method of contraception while on treatment with Graftide M 500mg Tablet.
• Your physician will regularly conduct blood tests to check for changes in your blood cells and detect signs of infections.
• Do not donate your sperms while being treated with this medication and  avoid it for at least 90 days after the end of the treatment.

Additional Information:

Approx. Rs 8,400 / VialGet Latest Price

Brand Name: Bevatas  

Generic Name: Bevacizumab

Company: Intas

Strength: 100mg/4ml

Indication:

Bevacizumab is approved to be used alone or with other drugs to treat:

·         Cervical cancer that has not gotten better with other treatment, has metastasized (spread to other parts of the body), or has recurred (come back).

·         Colorectal cancer that has metastasized.

·         Nonsquamous non-small cell lung cancer that is locally advanced, cannot be removed by surgery, has metastasized, or has recurred.

·         Ovarian epithelial, fallopian tube, or primary peritoneal cancer. It is used in patients with stage III, stage IV, or recurrent disease.

·         Renal cell carcinoma (a type of kidney cancer) that has metastasized.

Bevacizumab is also being studied in the treatment of other types of cancer

Dosage:

Bevacizumab is given by infusion into a vein by a health care professional. The first dose is usually given over 90 minutes. If you tolerate the first dose well, then later infusions may be given over a shorter time (60 or 30 minutes).

The dosage is based on your medical condition, response to previous therapy, and your weight. Tell your doctor if your weight changes.

Use this medication regularly in order to get the most benefit from it. Try not to miss any doses.

Side Effects

Dry mouth, cough, voice changes, loss of appetite, diarrhea, vomiting, constipation, mouthsores, nausea, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist right away.

Before using bevacizumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Additional Information:

Approx. Rs 19,250 / VialGet Latest Price

Brand Name: Cizumab  

Generic Name: Bevacizumab

Company: Hetero

Strength: 100mg/4ml

Indication:

Bevacizumab is approved to be used alone or with other drugs to treat:

·         Cervical cancer that has not gotten better with other treatment, has metastasized (spread to other parts of the body), or has recurred (come back).

·         Colorectal cancer that has metastasized.

·         Nonsquamous non-small cell lung cancer that is locally advanced, cannot be removed by surgery, has metastasized, or has recurred.

·         Ovarian epithelial, fallopian tube, or primary peritoneal cancer. It is used in patients with stage III, stage IV, or recurrent disease.

·         Renal cell carcinoma (a type of kidney cancer) that has metastasized.

Bevacizumab is also being studied in the treatment of other types of cancer

Dosage:

Bevacizumab is given by infusion into a vein by a health care professional. The first dose is usually given over 90 minutes. If you tolerate the first dose well, then later infusions may be given over a shorter time (60 or 30 minutes).

The dosage is based on your medical condition, response to previous therapy, and your weight. Tell your doctor if your weight changes.

Use this medication regularly in order to get the most benefit from it. Try not to miss any doses.

Side Effects

Dry mouth, cough, voice changes, loss of appetite, diarrhea, vomiting, constipation, mouthsores, nausea, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist right away.

Before using bevacizumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Approx. Rs 10,500 / VialGet Latest Price

Brand Name: MABTAS RA

Generic Name: Rituximab

Company: Intas

Strength: 500mg/50ml

Indications:

Rituximab is used to treat certain types of cancer (such as non-Hodgkin's lymphoma, chronic lymphocytic leukemia). It works by slowing or stopping the growth of cancer cells.       

How to use Rituximab        

Read the Medication Guide provided by your pharmacist before you start using rituximab and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Side Effects

Nausea, vomiting, headache, dizziness, joint/muscle pain, weakness, or flushing may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Precautions

Before using rituximab, tell your doctor or pharmacist if you are allergic to it; or to mouse protein; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

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Additional Information:

Approx. Rs 3,100 / BottleGet Latest Price

Indication:   

Treating non-small cell lung cancer after other cancer chemotherapy treatments have not been successful. It may also be used for other conditions as determined by your doctor.

Geftinat (Gefitinib ) is a cancer chemotherapy agent. It works by blocking a certain protein (an enzyme called tyrosine kinase). This helps to stop the cancer from growing and spreading.

Dosage and Administration:

• Geftinat (Gefitinib ) is a pill, taken by mouth, once daily.  It can be taken with or without food.
• The amount of Geftinat (Gefitinib ) that you will receive depends on many factors, your general health or other health problems, and the type of cancer or condition being treated.  Current recommendation is for one tablet daily, higher doses do not give a better response and may cause increased toxicity.  Your doctor will determine your dose and schedule.

Additional Information:

Approx. Rs 18,100 / PackGet Latest Price

GENERIC NAME: hylan G-F 20

BRAND NAME: Synvisc, Synvisc-One

Indication: Hylan G-F 20 is used for treating pain caused by osteoarthritis of the knee.

DOSING&STORAGE: hyland G-F 20 should be stored at room temperature, below 86 F (30 C). Any unused solution should be thrown out. It should not be frozen Hylan G-F 20 is injected into the knee by a health professional. A course of treatment consists of three injections with each injection seven days apart when using Synvisc. Alternatively Synvisc-One, which contains all 3 doses (48 mg/ 6 ml) can be injected once as a single injection. Most people experience the greatest amount of relief from pain 8 to 12 weeks after beginning treatment. Some patients will require more than one course of treatment.

SIDE EFFECTS: About 1 in 14 persons experience pain or swelling in the injected knee, and one third of those who do, need to have fluid removed from the knee. Side effects include:

· injection site pain,

· injection site stiffness,

· injection site redness,

· skin rash,

· itching,

· facial flushing and

· facial swelling.

PREPARATIONS: Injection: 16 mg/2 ml, 48 mg/6 ml

Approx. Rs 6,900 / BottleGet Latest Price

Indication:

This medication is used to treat kidney or liver cancer. It may also be used to treat a certain type of thyroid cancer (differentiated thyroid carcinoma). Sorafenat   (Sorafenib Tosylate)  stops or slows the growth of cancer cells (tumors). It also works by slowing the growth of new blood vessels within the tumor.

Dosage Administration:

Take this medication by mouth on an empty stomach (at least 1 hour before or 2 hours after a meal) as directed by your doctor, usually twice a day. 

Approx. Rs 5,000 / StripGet Latest Price

Brand Name: Azel

Generic Name: Enzalutamide

Company Name: Dr.Reddys

Strength: 40mg

Packing: 4x28 Capsules

Indications:

Enzalutamide is used to treat prostate cancer that has spread to other parts of the body in men who have not been helped by other medical and surgical treatments including docetaxel (Docefrez, Taxotere). Enzalutamide is in a class of medications called androgen receptor inhibitors. It works by blocking the effects of androgen (a male reproductive hormone) to stop the growth and spread of cancer cells.

How to use:

Enzalutamide comes as a capsule to take by mouth. It is usually taken with or without food once a day. Take enzalutamide at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take enzalutamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not chew, dissolve, or open them.

Side Effects;

Hot flashes, headache, dizziness, If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Precautions

Before taking enzalutamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Approx. Rs 21,000 / PieceGet Latest Price

Canmab 440mg Injection consists of the active ingredient Trastuzumab. It is indicated to treat early-stage and metastatic breast cancer where the cancer cells develop due to overexpression of HER2 proteins. This medication is also used to treat metastatic gastric cancer with increased levels of HER2 proteins. Cancer occurs when the cells begin to grow abnormally and uncontrollably, and cancer that has begun to spread is termed metastatic cancer.

Canmab 440mg Injection is not recommended for patients aged under 18, patients who have severe breathing problems or need oxygen treatment. It is necessary to let your physician know if you have any heart problems, breathlessness, or have ever had any other cancer treatment. Make sure you inform your physician of all the medicines, including supplements and herbal medicines, you are taking before you start treatment with this medication.

Use effective birth control during the treatment and for at least 7 months after the final dose. Suppose you begin any new medication within seven months after the final dose. In that case, you must inform the health care professional that you have had Canmab 440mg Injection as this drug may take around 7 months to be eliminated from the body. 

Uses of Canmab 440mg Injection:

Canmab 440mg Injection is indicated to treat the following conditions:

• Early and metastatic breast cancer
• Metastatic gastric cancer

Additional Information:

Approx. Rs 135 / PieceGet Latest Price

We have carved a niche amongst the most trusted names in this business, engaged in offering comprehensive range of Cytodrox Capsule.

Features:

• High purity
• Pleasing aroma
• Long shelf life

Approx. Rs 12,000 / PieceGet Latest Price

Brand name: Bortecad

Active Ingeridents(Generic Name) : Bortezomib Inj

Company Name: Cadila

Package: 1 vial

Strength : 2mg

Indication:

It is the first therapeutic proteasome inhibitor to be tested in humans. Proteasomes are cellular complexes that break down proteins. In some cancers, the proteins that normally kill cancer cells are broken down too quickly. Bortezomib interrupts this process and lets those proteins kill the cancer cells. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma. In multiple myeloma, complete clinical responses have been obtained in patients with otherwise refractory or rapidly advancing disease.

Mechanism of action:

The boron atom in bortezomib binds the catalytic site of the 26S proteasome^] with high affinity and specificity. In normal cells, the proteasome regulates protein expression and function by degradation of ubiquitylated proteins, and also cleanses the cell of abnormal or misfolded proteins. Clinical and preclinical data support a role in maintaining the immortal phenotype of myeloma cells, and cell-culture and xenograft data support a similar function in solid tumor cancers.

Dosage and Administration:

Use bortezomib as directed by your doctor. Check the label on the medicine for exact dosing instructions.

· Drinking extra fluids while you are taking bortezomib is recommended. Check with your doctor for instructions.

· Bortezomib is given as an injection into a vein or under the skin at your doctor's office, hospital, or clinic. Bortezomib is not intended to be injected into the spinal cord. Contact your health care provider if you have any questions.

· It is very important that each dose is given at the scheduled time. If you miss a dose of bortezomib, contact your doctor right away to establish a new dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use bortezomib.

Side effects:

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; headache; loss of appetite; mild stomach pain; nausea; stomach upset; taste changes; tiredness; trouble sleeping; vomiting; weakness.

 Precaution:

· Bortezomib may cause dizziness, fatigue, fainting, or vision changes. These effects may be worse if you take it with alcohol or certain medicines. Use bortezomib with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

· Bortezomib may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

 Store:

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.Keep out of the reach of children.Do not keep outdated medicine or medicine no longer needed.