AntiCancer Medicine

Approx. Rs 22,000 / StripGet Latest Price

Brand Name: Bdenza

Generic Name: Enzalutamide

Company Name: BDR Pharmaceuticals

Strength: 40mg

Packing: 4x28 Capsules

Indications:

Enzalutamide is used to treat prostate cancer that has spread to other parts of the body in men who have not been helped by other medical and surgical treatments including docetaxel (Docefrez, Taxotere). Enzalutamide is in a class of medications called androgen receptor inhibitors. It works by blocking the effects of androgen (a male reproductive hormone) to stop the growth and spread of cancer cells.

How to use:

Enzalutamide comes as a capsule to take by mouth. It is usually taken with or without food once a day. Take enzalutamide at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take enzalutamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not chew, dissolve, or open them.

Side Effects;

Hot flashes, headache, dizziness, If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Precautions

Before taking enzalutamide, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Approx. Rs 17,640 / PieceGet Latest Price

Brand name: Bortenat

Active Ingeridents(Generic Name) : Bortezomib

Company Name: Natco Pharma

Package: 1 vial

Strength : 3.5mg

Indication:

It is the first therapeutic proteasome inhibitor to be tested in humans. Proteasomes are cellular complexes that break down proteins. In some cancers, the proteins that normally kill cancer cells are broken down too quickly. Bortezomib interrupts this process and lets those proteins kill the cancer cells. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma. In multiple myeloma, complete clinical responses have been obtained in patients with otherwise refractory or rapidly advancing disease.

Mechanism of action:

The boron atom in bortezomib binds the catalytic site of the 26S proteasome^] with high affinity and specificity. In normal cells, the proteasome regulates protein expression and function by degradation of ubiquitylated proteins, and also cleanses the cell of abnormal or misfolded proteins. Clinical and preclinical data support a role in maintaining the immortal phenotype of myeloma cells, and cell-culture and xenograft data support a similar function in solid tumor cancers.

Dosage and Administration:

Use bortezomib as directed by your doctor. Check the label on the medicine for exact dosing instructions.

· Drinking extra fluids while you are taking bortezomib is recommended. Check with your doctor for instructions.

· Bortezomib is given as an injection into a vein or under the skin at your doctor's office, hospital, or clinic. Bortezomib is not intended to be injected into the spinal cord. Contact your health care provider if you have any questions.

· It is very important that each dose is given at the scheduled time. If you miss a dose of bortezomib, contact your doctor right away to establish a new dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use bortezomib.

Side effects:

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; headache; loss of appetite; mild stomach pain; nausea; stomach upset; taste changes; tiredness; trouble sleeping; vomiting; weakness.

Precaution:

· Bortezomib may cause dizziness, fatigue, fainting, or vision changes. These effects may be worse if you take it with alcohol or certain medicines. Use bortezomib with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

· Bortezomib may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

Store:

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.Keep out of the reach of children.Do not keep outdated medicine or medicine no longer needed.  

Approx. Rs 340 / StripGet Latest Price

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Brand name Tacrograf¿¿

Active Ingeridents(Generic Name) Tacrolimus

Company Name Biocon¿¿

Package 10 caps In strip

Strength 1mg

Indication indicated for organ transplant rejection prophylaxis. Patients are prescribed this medicine after an organ transplant, so as to help prevent the immune system from attacking the organ and to stop the body rejecting the transplant.

Mechanism of action Tacrolimus is a macrolide calcineurin inhibitor. In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to activate calcineurin. Calcineurin then dephosphorylates the transcription factor nuclear factor of activated T-cells (NF-AT), which moves to the nucleus of the T-cell and increases the activity of genes coding for IL-2 and related cytokines. Tacrolimus prevents the dephosphorylation of NF-AT. In detail, Tacrolimus reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin, thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription. Although this activity is similar to that of ciclosporin, the incidence of acute rejection is reduced by tacrolimus use over ciclosporin. Although short-term immunosuppression concerning patient and graft survival is found to be similar between the two drugs, tacrolimus results in a more favorable lipid profile, and this may have important long-term implications given the prognostic influence of rejection on graft survival.¿¿

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Dosage and Administration Oral tacrolimus is taken twice daily. Starting doses range between 0.075 mg/kg/day to 0.2 mg/kg/day. Doses vary widely and are based on tests that measure the amount of tacrolimus in the blood. Taking tacrolimus with food can reduce some of the abdominal pain that can occur with this medicine; however, food can reduce the amount of tacrolimus that is absorbed. This is especially true with fatty foods. Capsules should be taken consistently with or without food in order to avoid major swings in blood levels. Grapefruit juice increases blood levels of tacrolimus and should be avoided. The injection is only used for patients who cannot tolerate tacrolimus capsules.¿¿

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Side effects

Tacrolimus is associated with many and various side effects. These include

¿¿ baldness,anemia,loss of appetite,diarrhea,high concentrations of potassium in the blood,high blood pressure, nausea, vomiting, ,tingling sensation in the extremities, itching, tremor, fever, headache, rash, high blood sugar concentrations, and, abdominal pain.

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Precaution

An overdose Tacrolimus Unlikely to threaten life, call an emergency room or a poison control center for advice if you suspect that a very large dose of Tacrolimus has been ingested.

There are no restrictions on food, beverages, or activities while taking Tacrolimus otherwise directed by your physician.¿¿

Store Tacrolimus is usually handled and stored by a health care provider. If you are using tacrolimus at home, store tacrolimus as directed by your pharmacist or health care provider. Keep tacrolimus out of the reach of children and away from pets.

Approx. Rs 1,100 / StripGet Latest Price

It is used in the treatment of intermediate or high-risk myelofibrosis, a type of myeloproliferative disorder that affects the bone marrow, and for polycythemia vera (PCV) when there has been an inadequate response to or intolerance of hydroxyurea.

Mechanism of action:

Capnat Medicines is a Janus kinase inhibitor with selectivity for subtypes JAK1 and JAK2 of this enzyme. Ruxolitinib inhibits dysregulated JAK signaling associated with myelofibrosis. JAK1 and JAK2 recruit signal transducers and activators of transcription (STATs) to cytokine receptors leading to modulation of gene expression.

Dosage and Administration:

Capnat Medicines is a pill, taken by mouth, with or without food. Take ruxolitinib exactly as prescribed, even if you are feeling better. Swallow ruxolitinib tablets whole. Do not chew, crush or break.

Side Effects:

Side effects include thrombocytopenia (low blood platelet count), anemia (low red blood cell count) and neutropenia; risk of infection; symptom exacerbation if the medication is interrupted or discontinued; and non-melanoma skin cancer.

Immunologic side effects have included herpes zoster (shingles) and case reports of opportunistic infections. Metabolic side effects have included weight gain. Laboratory abnormalities have included alanine transaminase (ALT) abnormalities, aspartate transaminase (AST) abnormalities, and mildly elevated cholesterol levels.

Precaution:

• Capnat Medicinesmay interact with many types of medications . Before starting ruxolitinib treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
• Do not receive any kind of immunization or vaccination without your doctor''s approval while taking ruxolitinib.
• Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category C (use in pregnancy only when benefit to the mother outweighs risk to the fetus).

Store: Store Capnat Medicines at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep abiraterone acetate out of the reach of children and away from pets.

• Minimum Order Quantity: 1 14 Tabs in strip

Approx. Rs 26,775 / PackGet Latest Price

Approx. Rs 15,864 / PackGet Latest Price

Approx. Rs 8,880 / BottleGet Latest Price

Indication:

This medication is used to treat kidney or liver cancer. It may also be used to treat a certain type of thyroid cancer (differentiated thyroid carcinoma). Sorafenat   (Sorafenib Tosylate)  stops or slows the growth of cancer cells (tumors). It also works by slowing the growth of new blood vessels within the tumor.

Dosage Administration:

Take this medication by mouth on an empty stomach (at least 1 hour before or 2 hours after a meal) as directed by your doctor, usually twice a day. 

Approx. Rs 12,000 / PieceGet Latest Price

Brand name: Bortecad

Active Ingeridents(Generic Name) : Bortezomib Inj

Company Name: Cadila

Package: 1 vial

Strength : 2mg

Indication:

It is the first therapeutic proteasome inhibitor to be tested in humans. Proteasomes are cellular complexes that break down proteins. In some cancers, the proteins that normally kill cancer cells are broken down too quickly. Bortezomib interrupts this process and lets those proteins kill the cancer cells. It is approved in the U.S. for treating relapsed multiple myeloma and mantle cell lymphoma. In multiple myeloma, complete clinical responses have been obtained in patients with otherwise refractory or rapidly advancing disease.

Mechanism of action:

The boron atom in bortezomib binds the catalytic site of the 26S proteasome^] with high affinity and specificity. In normal cells, the proteasome regulates protein expression and function by degradation of ubiquitylated proteins, and also cleanses the cell of abnormal or misfolded proteins. Clinical and preclinical data support a role in maintaining the immortal phenotype of myeloma cells, and cell-culture and xenograft data support a similar function in solid tumor cancers.

Dosage and Administration:

Use bortezomib as directed by your doctor. Check the label on the medicine for exact dosing instructions.

· Drinking extra fluids while you are taking bortezomib is recommended. Check with your doctor for instructions.

· Bortezomib is given as an injection into a vein or under the skin at your doctor's office, hospital, or clinic. Bortezomib is not intended to be injected into the spinal cord. Contact your health care provider if you have any questions.

· It is very important that each dose is given at the scheduled time. If you miss a dose of bortezomib, contact your doctor right away to establish a new dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use bortezomib.

Side effects:

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; headache; loss of appetite; mild stomach pain; nausea; stomach upset; taste changes; tiredness; trouble sleeping; vomiting; weakness.

 Precaution:

· Bortezomib may cause dizziness, fatigue, fainting, or vision changes. These effects may be worse if you take it with alcohol or certain medicines. Use bortezomib with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.

· Bortezomib may cause dizziness, light-headedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.

 Store:

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.Keep out of the reach of children.Do not keep outdated medicine or medicine no longer needed.  

Approx. Rs 600 / StripGet Latest Price

It is used in the treatment of intermediate or high-risk myelofibrosis, a type of myeloproliferative disorder that affects the bone marrow, and for polycythemia vera (PCV) when there has been an inadequate response to or intolerance of hydroxyurea.

 Mechanism of action:

Capegard 500mg Tablet is a Janus kinase inhibitor with selectivity for subtypes JAK1 and JAK2 of this enzyme. Ruxolitinib inhibits dysregulated JAK signaling associated with myelofibrosis. JAK1 and JAK2 recruit signal transducers and activators of transcription (STATs) to cytokine receptors leading to modulation of gene expression.

Dosage and Administration:

Capegard 500mg Tablet is a pill, taken by mouth, with or without food. Take ruxolitinib exactly as prescribed, even if you are feeling better. Swallow ruxolitinib tablets whole. Do not chew, crush or break.

Side Effects:

Side effects include thrombocytopenia (low blood platelet count), anemia (low red blood cell count) and neutropenia; risk of infection; symptom exacerbation if the medication is interrupted or discontinued; and non-melanoma skin cancer.

Immunologic side effects have included herpes zoster (shingles) and case reports of opportunistic infections. Metabolic side effects have included weight gain. Laboratory abnormalities have included alanine transaminase (ALT) abnormalities, aspartate transaminase (AST) abnormalities, and mildly elevated cholesterol levels.

Precaution:

• Capegard 500mg Tablet may interact with many types of medications . Before starting ruxolitinib treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.).
• Do not receive any kind of immunization or vaccination without your doctor''s approval while taking ruxolitinib.
• Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category C (use in pregnancy only when benefit to the mother outweighs risk to the fetus).

Store: Store Capegard 500mg Tablet at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep abiraterone acetate out of the reach of children and away from pets. 

• Minimum Order Quantity: 1 14 Tabs in strip

Approx. Rs 11,300 / PackGet Latest Price

Approx. Rs 34,350 / StripGet Latest Price

Brand Name:  Glenza

Generic Name: Enzalutamide

Company Name: Glenmark

Strength: 40mg

Packing:  4x28 Capsules

Indications:

Enzalutamide is used to treat prostate cancer that has spread to other parts of the body in men who have not been helped by other medical and surgical treatments including docetaxel (Docefrez, Taxotere). Enzalutamide is in a class of medications called androgen receptor inhibitors. It works by blocking the effects of androgen (a male reproductive hormone) to stop the growth and spread of cancer cells.

How to use:

Enzalutamide comes as a capsule to take by mouth. It is usually taken with or without food once a day. Take enzalutamide at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take enzalutamide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not chew, dissolve, or open them.

Side Effects;

Hot flashes, headache, dizziness, If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Precautions

Additional Information:

Approx. Rs 55,000 / BoxGet Latest Price

Brand Name: Hertraz  

Generic Name : Trastuzumab Injection
Company Name: Mylan

Strength : 440mg

Indications:

Trastuzumab is a prescription medication used to treat breast cancer and stomach cancer.  It may be used alone or in combination with other medications. Trastuzumab belongs to a group of drugs called monoclonal antibodies, which help stop the growth of cancer cells.

Dosage:

This medication comes in an injectable form and is given into the vein (IV) by a healthcare provider once every week or once every 3 weeks.

Common side effects of trastuzumab include fever, nausea, and vomiting.

Precautions:

Before using trastuzumab, tell your doctor or pharmacist if you are allergic to it; or to other mouse protein medications; or if you have any other allergies. This product may contain inactive ingredients (such as benzyl alcohol), which can cause allergic reactions or other problems. Talk to your pharmacist for more details. See also Warning section.

Approx. Rs 28,500 / VialGet Latest Price

Brand Name: Bevarest

Generic Name: Bevacizumab

Company: Emcure

Strength: 100mg/4ml

Indication:

Bevacizumab is approved to be used alone or with other drugs to treat:

·         Cervical cancer that has not gotten better with other treatment, has metastasized (spread to other parts of the body), or has recurred (come back).

·         Colorectal cancer that has metastasized.

·         Nonsquamous non-small cell lung cancer that is locally advanced, cannot be removed by surgery, has metastasized, or has recurred.

·         Ovarian epithelial, fallopian tube, or primary peritoneal cancer. It is used in patients with stage III, stage IV, or recurrent disease.

·         Renal cell carcinoma (a type of kidney cancer) that has metastasized.

Bevacizumab is also being studied in the treatment of other types of cancer

Dosage:

Bevacizumab is given by infusion into a vein by a health care professional. The first dose is usually given over 90 minutes. If you tolerate the first dose well, then later infusions may be given over a shorter time (60 or 30 minutes).

The dosage is based on your medical condition, response to previous therapy, and your weight. Tell your doctor if your weight changes.

Use this medication regularly in order to get the most benefit from it. Try not to miss any doses.

Side Effects

Dry mouth, cough, voice changes, loss of appetite, diarrhea, vomiting, constipation, mouthsores, nausea, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist right away.

Before using bevacizumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Additional Information:

Approx. Rs 72,000 / VialGet Latest Price

Brand Name: Cizumab  

Generic Name: Bevacizumab

Company: Hetero

Strength: 100mg/4ml

Indication:

Bevacizumab is approved to be used alone or with other drugs to treat:

·         Cervical cancer that has not gotten better with other treatment, has metastasized (spread to other parts of the body), or has recurred (come back).

·         Colorectal cancer that has metastasized.

·         Nonsquamous non-small cell lung cancer that is locally advanced, cannot be removed by surgery, has metastasized, or has recurred.

·         Ovarian epithelial, fallopian tube, or primary peritoneal cancer. It is used in patients with stage III, stage IV, or recurrent disease.

·         Renal cell carcinoma (a type of kidney cancer) that has metastasized.

Bevacizumab is also being studied in the treatment of other types of cancer

Dosage:

Bevacizumab is given by infusion into a vein by a health care professional. The first dose is usually given over 90 minutes. If you tolerate the first dose well, then later infusions may be given over a shorter time (60 or 30 minutes).

The dosage is based on your medical condition, response to previous therapy, and your weight. Tell your doctor if your weight changes.

Use this medication regularly in order to get the most benefit from it. Try not to miss any doses.

Side Effects

Dry mouth, cough, voice changes, loss of appetite, diarrhea, vomiting, constipation, mouthsores, nausea, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist right away.

Before using bevacizumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Additional Information:

Approx. Rs 30,000 / VialGet Latest Price

Brand Name: MABALL

Generic Name: Rituximab

Company: Hetero

Strength: 500mg/50ml

Indications:

Rituximab is used to treat certain types of cancer (such as non-Hodgkin's lymphoma, chronic lymphocytic leukemia). It works by slowing or stopping the growth of cancer cells.       

How to use Rituximab        

Read the Medication Guide provided by your pharmacist before you start using rituximab and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Side Effects

Nausea, vomiting, headache, dizziness, joint/muscle pain, weakness, or flushing may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Precautions

Before using rituximab, tell your doctor or pharmacist if you are allergic to it; or to mouse protein; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Additional Information:

Approx. Rs 25,000 / VialGet Latest Price

Brand Name: Cizumab  

Generic Name: Bevacizumab

Company: Hetero

Strength: 100mg/4ml

Indication:

Bevacizumab is approved to be used alone or with other drugs to treat:

·         Cervical cancer that has not gotten better with other treatment, has metastasized (spread to other parts of the body), or has recurred (come back).

·         Colorectal cancer that has metastasized.

·         Nonsquamous non-small cell lung cancer that is locally advanced, cannot be removed by surgery, has metastasized, or has recurred.

·         Ovarian epithelial, fallopian tube, or primary peritoneal cancer. It is used in patients with stage III, stage IV, or recurrent disease.

·         Renal cell carcinoma (a type of kidney cancer) that has metastasized.

Bevacizumab is also being studied in the treatment of other types of cancer

Dosage:

Bevacizumab is given by infusion into a vein by a health care professional. The first dose is usually given over 90 minutes. If you tolerate the first dose well, then later infusions may be given over a shorter time (60 or 30 minutes).

The dosage is based on your medical condition, response to previous therapy, and your weight. Tell your doctor if your weight changes.

Use this medication regularly in order to get the most benefit from it. Try not to miss any doses.

Side Effects

Dry mouth, cough, voice changes, loss of appetite, diarrhea, vomiting, constipation, mouthsores, nausea, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist right away.

Before using bevacizumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Additional Information: