Anticancer Products

Approx. Rs 6,500 / BottleGet Latest Price

Resof L (Ledipasvir Sofosbuvir)

Brand name: Resof L

Active Ingeridents(Generic Name) : Ledipasvir Sofosbuvir

Company Name: Dr.Reddy’s

Package: 28 tablets/bottle

Strength : Ledipasvir 90mg Sofosbuvir 400mg

Indication:

Treating chronic hepatitis C virus (HCV) infection in certain patients.

Ledipasvir and sofosbuvir is a combination of 2 hepatitis C virus (HCV) antiviral agents. It reduces the amount of HCV in the body by preventing the spread of the HCV within the body.

Sofosbuvir and Ledipasvir is a combination and is used to treat chronic (long-lasting) hepatitis C, a viral infection of the liver.Sofosbuvir & Ledipasvir tablets, may sometimes be used with another antiviral medication (ribavirin). These drugs work by reducing the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. sofosbuvir ledipasvir , ledipasvir and sofosbuvir , ledipasvir and sofosbuvir cost, ledipasvir & sofosbuvir tablets, sofosbuvir ledipasvir price.

Mechanism of action:

Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion. Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication. The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.

Dosage and Administration:

Ledipasvir-sofosbuvir (90 mg/400 mg) is a fixed-dose combination tablet . The recommended dosage is one tablet once daily, with or without food.

Side effects:

The following are the Common side effects

· fatigue

• nausea
• headache
• diarrhea

· insomnia

Precaution:

· Tell your doctor or dentist that you take ledipasvir and sofosbuvir before you receive any medical or dental care, emergency care, or surgery.

· Do not share needles, injection supplies, or items like toothbrushes or razors. Talk with your health care provider about ways to prevent the spread of HCV to others.

Store: ledipasvir Sofosbuvir  room temperature away from moisture and heat 

Additional Information:

Approx. Rs 8,800 / PackGet Latest Price

Rasburnat (Rasburicase)

• Brand name: Rasburnat
• Active Ingeridents(Generic Name) : Rasburicase
• Company Name: Natco
• Package: Vial
• Strength: 1.5mg

Indication:

This medicine is Preventing high blood levels of uric acid from occurring in patients with certain types of cancer (eg, leukemia, lymphoma, solid malignant tumors) who are receiving cancer chemotherapy treatment.

Rasburnat (Rasburicase) is a urate-oxidase enzyme. When chemotherapy is given, cancer cells are destroyed, releasing large amounts of uric acid into the blood. Rasburnat (Rasburicase) works by allowing uric acid to be more easily removed from the body by the kidneys.

Mechanism of action:

In humans, uric acid is the final step in the catabolic pathway of purines. Rasburnat (Rasburicase) catalyzes enzymatic oxidation of poorly soluble uric acid into an inactive and more soluble metabolite allantoin with carbon dioxide and hydrogen peroxide as byproducts in the chemical reaction.

Dosage and Administration:

Use Rasburnat (Rasburicase) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

· Rasburnat (Rasburicase) is usually given as an injection at your doctor's office, hospital, or clinic. Ask your doctor or pharmacist any questions that you may have about Rasburnat (Rasburicase).

· Do not shake Rasburnat (Rasburicase).

· Do not use Rasburnat (Rasburicase) if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.

· Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

· If you miss a dose of Rasburnat (Rasburicase), contact your doctor immediately to establish a new dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Rasburnat (Rasburicase).

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; headache; mouth sores or ulcers; nausea; stomach pain; vomiting.

Precaution:

Also see the Warnings section.

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Store:

Rasburnat (Rasburicase) is usually handled and stored by a health care provider. If you are using Rasburnat (Rasburicase) at home, store Rasburnat (Rasburicase) as directed by your pharmacist or health care provider. Keep Rasburnat (Rasburicase) out of the reach of children and away from pets.

Approx. Rs 396 / StripGet Latest Price

Brand Name ??Lanolimus 0.25mg

Generic Name ??Everolimus

Company Mylan

Strength0.25mg

Packing ??1x10 Tablets

Indication

Everolimus is used to treat various types of cancer (such as kidney, breast, pancreas, lung, stomach/intestinal cancers). Everolimus is also used in people with a certain genetic disorder (tuberous sclerosis complex) to treat certain types of benign tumors in the brain or kidney. It works by slowing or stopping the growth of cancer or tumor cells.

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How to use Everolimus

Take this medication by mouth as directed by your doctor, usually once daily. You may take this medication with or without food, but it is important to choose one way and take this medication the same way with every dose. Swallow this medication whole with a glass of water. Do not crush or chew the tablets.

Read the Patient Information Leaflet if available from your pharmacist before you start taking everolimus and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Do not change dosage forms of this medication without checking with your doctor or pharmacist.

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Side Effects

Diarrhea, nausea/vomiting, decreased appetite, weight loss, changes in taste, nosebleeds, dry skin, dizziness, and headache may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

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Precautions

Before taking everolimus, tell your doctor or pharmacist if you are allergic to it; or to sirolimus or temsirolimus; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Approx. Rs 390 / PackGet Latest Price

Brand name: Daunotec

Active Ingeridents (Generic Name) : Daunorubicin

Company Name: Cipla

Package: Vial

Strength : 20mg

Indication:It is used in the treatment of Acute Myelogenous Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL). It may be used in combination with other medicines. It may also be used for other conditions as determined by your doctor.

Mechanism of action:

Daunotec (Daunorubicin) has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Daunotec (Daunorubicin) forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Dosage & Administration:

• Daunotec (Daunorubicin) is given by intravenous injection (IV). The syringe needle is placed directly into the tubing of a freely flowing IV solution into a vein or central line and the drug is given over several minutes.
• Daunotec (Daunorubicin) is a vesicant. A vesicant is a chemical that causes extensive tissue damage and blistering if it escapes from the vein. The nurse or doctor who gives this drug must be carefully trained. If you notice redness or swelling at the IV site while you are receiving Daunotec (Daunorubicin) , alert your health care professional immediately.
• The amount of Daunotec (Daunorubicin) you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer you have. Your doctor will determine your dose and schedule.

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; hair loss; loss of appetite; mouth pain; nausea; sore throat; stomach pain; tiredness; weakness.

Precaution:

• Before starting Daunotec (Daunorubicin) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take , products containing unless your doctor specifically permits this.
• Do not receive any kind of immunization or vaccination without your doctor's approval while taking Daunotec (Daunorubicin) .
• You may be more sensitive to sunlight, take extra care to avoid sun exposure.
• People with congestive heart failure, those who have already had high doses of this drug or a similar drug, and those with permanent problems with blood counts (bone marrow suppression) cannot receive this drug.

Store: Daunotec (Daunorubicin) is usually handled and stored by a health care provider. If you are using Daunotec (Daunorubicin) at home, store Daunotec (Daunorubicin) as directed by your pharmacist or health care provider. Keep Daunotec (Daunorubicin) out of the reach of children and away from pets.

Approx. Rs 16,871 / BottleGet Latest Price

Temonat (Temozolomide) 

Brand name: Temonat

Active Ingeridents(Generic Name) : Temozolomide 

Company Name: Natco

Package: 5 Capsules

Strength: 250mg

Indication:

It is used as a treatment of some brain cancers; as a second-line treatment for astrocytoma and a first-line treatment for glioblastoma multiforme.

Temonat (Temozolomide) is an antineoplastic agent. It works by stopping cancer cells from growing and reproducing.

Mechanism of action:

The therapeutic benefit of Temonat (Temozolomide) depends on its ability toalkylate/methylate DNA, which most often occurs at the N-7 or O-6 positions ofguanine residues. This methylation damages the DNA and triggers the death of tumor cells. However, some tumor cells are able to repair this type of DNA damage, and therefore diminish the therapeutic efficacy of Temonat (Temozolomide) , by expressing a protein O⁶-alkylguanine DNA alkyltransferase (AGT) encoded in humans by the O-6-methylguanine-DNA methyltransferase (MGMT) gene.In some tumors, epigenetic silencing of the MGMT gene prevents the synthesis of this enzyme, and as a consequence such tumors are more sensitive to killing by Temonat (Temozolomide) .Conversely, the presence of AGT protein in brain tumors predicts poor response to Temonat (Temozolomide) and these patients receive little benefit from chemotherapy with Temonat (Temozolomide) . 

Dosage and Administration:

• This medication is given in a capsule form by mouth.
• Take on an empty stomach (1 hour before or 2 hours after meals or at bedtime) to reduce stomach upset.
• Do not open, crush, or chew capsules; swallow capsules whole with full 8 ounces of water.
• The frequency and the amount of this medication you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer you have. Your doctor will determine your dosage and schedule.

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; back pain; breast pain; constipation; cough; diarrhea; dizziness; drowsiness; dry skin; hair loss; headache; joint pain; loss of appetite; mild stomach pain; mouth or tongue sores; muscle aches; nausea; taste changes; tiredness; trouble sleeping; vomiting; weakness; weight gain.

Precaution:

• Before starting Temonat (Temozolomide) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take , or products containing aspirin unless your doctor specifically permits this.
• Do not receive any kind of immunization or vaccination without your doctor''s approval while taking Temonat (Temozolomide) .
• Let your health care provider know if you''ve had an allergic reaction to this drug or dacarbazine (DTIC) in the past, you may not be able to take temozolamide.

Store: Temonat (Temozolomide) is usually handled and stored by a health care provider. If you are using Temonat (Temozolomide) at home, store Temonat (Temozolomide) as directed by your pharmacist or health care provider. Keep Temonat (Temozolomide) out of the reach of children and away from pets.

Approx. Rs 9,500 / BottleGet Latest Price

Temodol (Temozolomide) 

Brand name: Temodol

Active Ingeridents(Generic Name) : Temozolomide 

Company Name: Schering -plough

Package: 5 Capsules

Strength: 20mg/Cap

Indication:

It is used as a treatment of some brain cancers; as a second-line treatment for astrocytoma and a first-line treatment for glioblastoma multiforme.

Temodol (Temozolomide) is an antineoplastic agent. It works by stopping cancer cells from growing and reproducing.

Mechanism of action:

The therapeutic benefit of Temodol (Temozolomide) depends on its ability toalkylate/methylate DNA, which most often occurs at the N-7 or O-6 positions ofguanine residues. This methylation damages the DNA and triggers the death of tumor cells. However, some tumor cells are able to repair this type of DNA damage, and therefore diminish the therapeutic efficacy of Temodol (Temozolomide), by expressing a protein O⁶-alkylguanine DNA alkyltransferase (AGT) encoded in humans by the O-6-methylguanine-DNA methyltransferase (MGMT) gene.In some tumors, epigenetic silencing of the MGMT gene prevents the synthesis of this enzyme, and as a consequence such tumors are more sensitive to killing by Temodol (Temozolomide).Conversely, the presence of AGT protein in brain tumors predicts poor response to Temodol (Temozolomide) and these patients receive little benefit from chemotherapy with Temodol (Temozolomide). 

Dosage and Administration:

• This medication is given in a capsule form by mouth.
• Take on an empty stomach (1 hour before or 2 hours after meals or at bedtime) to reduce stomach upset.
• Do not open, crush, or chew capsules; swallow capsules whole with full 8 ounces of water.
• The frequency and the amount of this medication you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer you have. Your doctor will determine your dosage and schedule.

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; back pain; breast pain; constipation; cough; diarrhea; dizziness; drowsiness; dry skin; hair loss; headache; joint pain; loss of appetite; mild stomach pain; mouth or tongue sores; muscle aches; nausea; taste changes; tiredness; trouble sleeping; vomiting; weakness; weight gain.

Precaution:

• Before starting Temodol (Temozolomide) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take , or products containing unless your doctor specifically permits this.
• Do not receive any kind of immunization or vaccination without your doctor''s approval while taking Temodol (Temozolomide).
• Let your health care provider know if you''ve had an allergic reaction to this drug or dacarbazine (DTIC) in the past, you may not be able to take temozolamide.

Store: Temodol (Temozolomide) is usually handled and stored by a health care provider. If you are using Temodol (Temozolomide) at home, store Temodol (Temozolomide) as directed by your pharmacist or health care provider. Keep Temodol (Temozolomide) out of the reach of children and away from pets.

Approx. Rs 12,990 / StripGet Latest Price

Approx. Rs 250 / StripGet Latest Price

Approx. Rs 3.13 Lakh / PackGet Latest Price

Lynparza Olaparib uses

Olaparib is used in the treatment of ovarian cancer.

How olaparib works

Olaparib is an anticancer medication. It works by stopping Poly-ADP-ribose polymerase (PARP) from working. PARP is a protein that helps cancer cells to repair themselves and continue to survive.

Approx. Rs 1,200 / PackGet Latest Price

Idrofos (Ibandronic acid) 

Brand name:Idrofos 3

Active Ingeridents (Generic Name) : Ibandronic acid

Company Name: Sun Pharma

Package: Vial

Strength : 3mg/3ml

Indication:

It is used in the prevention and treatment of osteoporosis and metastasis-associated skeletal fractures in people with cancer. It may also be used to treat hypercalcemia (elevated blood calcium levels).

Also, Treating osteoporosis (weak bones) in women who are past menopause. It may also be used for other conditions as determined by your doctor. Ibandronate is a bisphosphonate. It works by slowing bone loss and allowing new bone to be formed.

Mechanism of action:

The action of Idrofos (Ibandronic acid)on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting farnesyl pyrophosphate (FPP) synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.

Dosage & Administration:

Use Idrofos (Ibandronic acid)as directed by your doctor. Check the label on the medicine for exact dosing instructions.

· Idrofos (Ibandronic acid)comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Idrofos (Ibandronic acid)refilled.

· Idrofos (Ibandronic acid) is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.

· Ask your health care provider any questions you may have about how to use Idrofos (Ibandronic acid).

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; headache; heartburn; mild arm, back, leg, muscle, or joint pain; mild flu-like symptoms (eg, mild fever, chills, tiredness, weakness, joint or muscle aches); nausea; pain, swelling, or redness at the injection site; stomach pain or upset.

Precaution:

Before taking Idrofos (Ibandronic acid), tell your doctor or pharmacist if you are allergic to it; or to other bisphosphonates; or if you have any other allergies.

Store: Idrofos (Ibandronic acid)is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets..

Approx. Rs 37,000 / VialGet Latest Price

Brand Name: Reditux

Generic Name: Rituximab

Company: Dr.Reddy’s

Strength: 500mg

Indications:

Rituximab is used to treat certain types of cancer (such as non-Hodgkin's lymphoma, chronic lymphocytic leukemia). It works by slowing or stopping the growth of cancer cells.       

How to use Rituximab        

Read the Medication Guide provided by your pharmacist before you start using rituximab and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Side Effects

Nausea, vomiting, headache, dizziness, joint/muscle pain, weakness, or flushing may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Precautions

Before using rituximab, tell your doctor or pharmacist if you are allergic to it; or to mouse protein; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Additional Information:

Approx. Rs 850 / VialGet Latest Price

Approx. Rs 17,683 / PackGet Latest Price

Alimta (Pemetrexed )

Brand name: Alimta

Active Ingeridents(Generic Name) : Pemetrexed Inj

Company Name: Lilly

Package: 1 Vial

Strength: 100mg

Indication:

It is used in the treatment of pleural mesothelioma and non-small cell lung cancer.

Mechanism of action:

Alimta (Pemetrexed )is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites. It works by inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), andglycinamide ribonucleotide formyltransferase (GARFT). By inhibiting the formation of precursor purine and pyrimidine nucleotides, Alimta (Pemetrexed )prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells. 

Dosage and Administration:

Alimta (Pemetrexed ) is given as an infusion into the vein (intravenous, IV).

Patients treated with Alimta (Pemetrexed ) will usually require folic acid and vitamin B12 supplementation to reduce treatment related side effects.

The amount of Alimta (Pemetrexed ) that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. Your doctor will determine your dose and schedule.

Ask your health care provider any questions you may have about how to use Alimta (Pemetrexed )Inj.

Side effects:

The following side effects are common (occurring in greater than 30%) for patients taking Alimta (Pemetrexed ):

• Low white blood cell count. (This can put you at increased risk for infection), Low red blood cell count , Anemia), Fatigue, Nausea and vomiting, Constipation, Poor appetite, Shortness of breath, Chest pain

These side effects are less common side effects (occurring in about 10-29%) of patients receiving Alimta (Pemetrexed ):

· Low platelet count. (This can put you at increased risk for bleeding), Increase in blood test creatinine, Fever, Mouth sores, Numbness or tingling of hands or feet, Depression, Rash, skin irritation

Precaution:

Before using Alimta (Pemetrexed ), tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe kidney disease.

Store: Alimta (Pemetrexed )Injroom temperature away from moisture and heat.

Approx. Rs 370 / PIECEGet Latest Price

Daunorubitec (Daunorubicin)

Brand name: Daunorubitec

Active Ingeridents (Generic Name) : Daunorubicin

Company Name: United Biotech

Package: Vial

Strength : 20mg

Indication:

It is used in the treatment of Acute Myelogenous Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL). It may be used in combination with other medicines. It may also be used for other conditions as determined by your doctor.

Mechanism of action:

Daunorubitec (Daunorubicin) has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Daunorubitec (Daunorubicin) forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Dosage & Administration:

• Daunorubitec (Daunorubicin) is given by intravenous injection (IV). The syringe needle is placed directly into the tubing of a freely flowing IV solution into a vein or central line and the drug is given over several minutes.
• Daunorubitec (Daunorubicin) is a vesicant. A vesicant is a chemical that causes extensive tissue damage and blistering if it escapes from the vein. The nurse or doctor who gives this drug must be carefully trained. If you notice redness or swelling at the IV site while you are receiving Daunorubitec (Daunorubicin) , alert your health care professional immediately.
• The amount of Daunorubitec (Daunorubicin) you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer you have. Your doctor will determine your dose and schedule.

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; hair loss; loss of appetite; mouth pain; nausea; sore throat; stomach pain; tiredness; weakness.

Precaution:

• Before starting Daunorubitec (Daunorubicin) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take , products containing unless your doctor specifically permits this.
• Do not receive any kind of immunization or vaccination without your doctor's approval while taking Daunorubitec (Daunorubicin) .
• You may be more sensitive to sunlight, take extra care to avoid sun exposure.
• People with congestive heart failure, those who have already had high doses of this drug or a similar drug, and those with permanent problems with blood counts (bone marrow suppression) cannot receive this drug.

Store: Daunorubitec (Daunorubicin) is usually handled and stored by a health care provider. If you are using Daunorubitec (Daunorubicin) at home, store Daunorubitec (Daunorubicin) as directed by your pharmacist or health care provider. Keep Daunorubitec (Daunorubicin) out of the reach of children and away from pets.

Approx. Rs 1,570 / PackGet Latest Price

Bandrone (Ibandronic acid) 

Brand name: Bandrone

Active Ingeridents (Generic Name) : Ibandronic acid

Company Name: Natco

Package: Vial

Strength : 6mg

Indication:

It is used in the prevention and treatment of osteoporosis and metastasis-associated skeletal fractures in people with cancer. It may also be used to treat hypercalcemia (elevated blood calcium levels).

Also, Treating osteoporosis (weak bones) in women who are past menopause. It may also be used for other conditions as determined by your doctor. Ibandronate is a bisphosphonate. It works by slowing bone loss and allowing new bone to be formed.

Mechanism of action:

The action of Bandrone (Ibandronic acid)on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting farnesyl pyrophosphate (FPP) synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.

Dosage & Administration:

Use Bandrone (Ibandronic acid)as directed by your doctor. Check the label on the medicine for exact dosing instructions.

· Bandrone (Ibandronic acid)comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Bandrone (Ibandronic acid)refilled.

· Bandrone (Ibandronic acid) is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.

· Ask your health care provider any questions you may have about how to use Bandrone (Ibandronic acid).

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; headache; heartburn; mild arm, back, leg, muscle, or joint pain; mild flu-like symptoms (eg, mild fever, chills, tiredness, weakness, joint or muscle aches); nausea; pain, swelling, or redness at the injection site; stomach pain or upset.

Precaution:

Before taking Bandrone (Ibandronic acid), tell your doctor or pharmacist if you are allergic to it; or to other bisphosphonates; or if you have any other allergies.

Store: Bandrone (Ibandronic acid)is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.

Approx. Rs 18,000 / PackGet Latest Price

Fulvenat (Fulvestrant)

Brand name: Fulvenat 

Active Ingeridents (Generic Name) : Fulvestrant

Company Name: Natco 

Package: One prefilled syringe containing 5ml or 250mg Fulvenat (Fulvestrant)

Strength : 250mg/5ml

Indication:

Fulvenat (Fulvestrant) is an anti-estrogen medication. It works by blocking the actions of estrogen in the body. Certain types of breast cancer use estrogen to grow and multiply in the body.

Fulvenat (Fulvestrant) is used to treat a certain type of hormone-related breast cancer in postmenopausal women, when the cancer has spread to other parts of the body after treatment with anti-estrogen medication.

Fulvenat (Fulvestrant) is also used together with a medicine called palbociclib, to treat certain hormone-related breast cancer that has progressed or spread after treatment with hormonal therapy.

Mechanism of action:

Fulvenat (Fulvestrant) competitively and reversibly binds to estrogen receptors present in cancer cells and achieves its anti-estrogen effects through two separate mechanisms. First, Fulvenat (Fulvestrant) binds to the receptors and downregulates them so that estrogen is no longer able to bind to these receptors. Second, Fulvenat (Fulvestrant) degrades the estrogen receptors to which it is bound. Both of these mechanisms inhibit the growth of tamoxifen-resistant as well as estrogen-sensitive human breast cancer cell lines. 

Dosage & Administration:

As an injection into the muscle (intramuscular, IM), Fulvenat (Fulvestrant) is usually given as a once a month injection. Your doctor will determine any variations to this dosing or schedule.

Side effects:

Get emergency medical help if you have signs of an allergic reaction to Fulvenat (Fulvestrant): hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common Fulvenat (Fulvestrant) side effects may include:

Headache, bone pain, joint pain, muscle pain, nausea, vomiting, loss of appetite, constipation; weakness, feeling tired; cough, trouble breathing; abnormal liver function tests; hot flashes; or pain where the medicine was injected.

Precaution:

• Before starting Fulvenat (Fulvestrant) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take , or products containing unless your doctor specifically permits this.
• Let your health care professional know if you have ever had a blood clot that required medical treatment.
• Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (Fulvenat (Fulvestrant) may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus).

Store: Fulvenat (Fulvestrant) is handled and stored by a health care provider. Keep all medicines out of the reach of children and away from pets.

Approx. Rs 7,800 / PackGet Latest Price

Natdecita (Decitabine)

Brand name: Natdecita

Active Ingeridents(Generic Name) : Decitabine

Company Name: Natco

Package: Vial

Strength: 50mg

Indication:

This medicine is Treating myelodysplastic syndromes (MDS) (eg, certain types of anemia or leukemia). Natdecita (Decitabine)is a nucleoside analog. It works by blocking cell growth.

Mechanism of action:

Natdecita (Decitabine) is a hypomethylating agent. It hypomethylates DNA by inhibiting DNA methyltransferase.

It functions in a similar manner to azacitidine, although Natdecita (Decitabine)can only be incorporated into DNA strands while azacitidine can be incorporated into both DNA and RNA chains.

Dosage and Administration:

• As an infusion into the vein (intravenous or IV).
• The actual dosage of Natdecita (Decitabine)that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition you have. Your doctor will determine your exact dosage and schedule.

Side effects:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; cough; diarrhea; dizziness; hair loss; headache; joint or muscle pain; loss of appetite; nausea; stomach pain or upset; trouble sleeping; vomiting.

Precaution:

• Before starting Natdecita (Decitabine)treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take , products containing unless your doctor specifically permits this.
• Do not receive any kind of immunization or vaccination without your doctor’s approval while taking Decitabine.

Store: Natdecita (Decitabine)is usually handled and stored by a health care provider. If you are using Natdecita (Decitabine)at home, store Natdecita (Decitabine)as directed by your pharmacist or health care provider. Keep Natdecita (Decitabine)out of the reach of children and away from pets.