Anticancer Products

Approx. Rs 6,500 / BottleGet Latest Price

Resof L (Ledipasvir Sofosbuvir)

Brand name: Resof L

Active Ingeridents(Generic Name) : Ledipasvir Sofosbuvir

Company Name: Dr.Reddy’s

Package: 28 tablets/bottle

Strength : Ledipasvir 90mg Sofosbuvir 400mg

Indication:

Treating chronic hepatitis C virus (HCV) infection in certain patients.

Ledipasvir and sofosbuvir is a combination of 2 hepatitis C virus (HCV) antiviral agents. It reduces the amount of HCV in the body by preventing the spread of the HCV within the body.

Sofosbuvir and Ledipasvir is a combination and is used to treat chronic (long-lasting) hepatitis C, a viral infection of the liver.Sofosbuvir & Ledipasvir tablets, may sometimes be used with another antiviral medication (ribavirin). These drugs work by reducing the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. sofosbuvir ledipasvir , ledipasvir and sofosbuvir , ledipasvir and sofosbuvir cost, ledipasvir & sofosbuvir tablets, sofosbuvir ledipasvir price.

Mechanism of action:

Ledipasvir is a potent inhibitor of HCV NS5A, a viral phosphoprotein that plays an important role in viral replication, assembly, and secretion. Sofosbuvir is a nucleotide analog inhibitor of hepatitis C virus NS5B polymerase—the key enzyme mediating HCV RNA replication. The triphosphate form of sofosbuvir (GS-461203) mimics the natural cellular uridine nucleotide and is incorporated by the HCV RNA polymerase into the elongating RNA primer strand, resulting in viral chain termination.

Dosage and Administration:

Ledipasvir-sofosbuvir (90 mg/400 mg) is a fixed-dose combination tablet . The recommended dosage is one tablet once daily, with or without food.

Side effects:

The following are the Common side effects

· fatigue

• nausea
• headache
• diarrhea

· insomnia

Precaution:

· Tell your doctor or dentist that you take ledipasvir and sofosbuvir before you receive any medical or dental care, emergency care, or surgery.

· Do not share needles, injection supplies, or items like toothbrushes or razors. Talk with your health care provider about ways to prevent the spread of HCV to others.

Store: ledipasvir Sofosbuvir  room temperature away from moisture and heat 

Additional Information:

Approx. Rs 250 / StripGet Latest Price

Approx. Rs 14,220 / UnitGet Latest Price

Approx. Rs 8,800 / PackGet Latest Price

Rasburnat (Rasburicase)

• Brand name: Rasburnat
• Active Ingeridents(Generic Name) : Rasburicase
• Company Name: Natco
• Package: Vial
• Strength: 1.5mg

Indication:

This medicine is Preventing high blood levels of uric acid from occurring in patients with certain types of cancer (eg, leukemia, lymphoma, solid malignant tumors) who are receiving cancer chemotherapy treatment.

Rasburnat (Rasburicase) is a urate-oxidase enzyme. When chemotherapy is given, cancer cells are destroyed, releasing large amounts of uric acid into the blood. Rasburnat (Rasburicase) works by allowing uric acid to be more easily removed from the body by the kidneys.

Mechanism of action:

In humans, uric acid is the final step in the catabolic pathway of purines. Rasburnat (Rasburicase) catalyzes enzymatic oxidation of poorly soluble uric acid into an inactive and more soluble metabolite allantoin with carbon dioxide and hydrogen peroxide as byproducts in the chemical reaction.

Dosage and Administration:

Use Rasburnat (Rasburicase) as directed by your doctor. Check the label on the medicine for exact dosing instructions.

· Rasburnat (Rasburicase) is usually given as an injection at your doctor's office, hospital, or clinic. Ask your doctor or pharmacist any questions that you may have about Rasburnat (Rasburicase).

· Do not shake Rasburnat (Rasburicase).

· Do not use Rasburnat (Rasburicase) if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.

· Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.

· If you miss a dose of Rasburnat (Rasburicase), contact your doctor immediately to establish a new dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Rasburnat (Rasburicase).

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; headache; mouth sores or ulcers; nausea; stomach pain; vomiting.

Precaution:

Also see the Warnings section.

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Store:

Rasburnat (Rasburicase) is usually handled and stored by a health care provider. If you are using Rasburnat (Rasburicase) at home, store Rasburnat (Rasburicase) as directed by your pharmacist or health care provider. Keep Rasburnat (Rasburicase) out of the reach of children and away from pets.

Approx. Rs 306 / StripGet Latest Price

Brand Name  Graftide -S 500mg

Generic Name  Mycophenolic Acid Delayed -Release Tablets.

Company Mylan

Strength 500mg

Packing  6 x10 Tablets

Indication

It is used to keep the body from harming the organ after an organ transplant. It may be given to you for other reasons. Talk with the doctor.

How to use  Graftide

Use this medicine (mycophenolic acid delayed-release tablets) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Take on an empty stomach at least 1 hour before or 2 hours after meals unless your doctor has told you otherwise.
• Do not take antacids that have magnesium or aluminum at the same time as this medicine (mycophenolic acid delayed-release tablets). Talk with your doctor or pharmacist.
• To gain the most benefit, do not miss doses.
• Keep taking this medicine (mycophenolic acid delayed-release tablets) as you have been told by your doctor or other health care provider, even if you feel well.
• Take this medicine (mycophenolic acid delayed-release tablets) at the same time of day.
• Swallow whole. Do not chew, break, or crush.
• If you have trouble swallowing, talk with your doctor.
• Do not switch brands or types of this medicine (mycophenolic acid delayed-release tablets) (like tablets, liquid) unless you talk with the doctor. They may not work the same.
• Talk with your doctor before getting any vaccines. Use with this medicine (mycophenolic acid delayed-release tablets) may either raise the chance of an infection or make the vaccine not work as well.
• You may need to avoid donating blood while taking this medicine (mycophenolic acid delayed-release tablets) and for some time after. Talk with your doctor.
• If you are a man, you may need to avoid donating sperm while taking this medicine (mycophenolic acid delayed-release tablets) and for some time after. Talk with your doctor.

Approx. Rs 6,450 / BottleGet Latest Price

Temonat (Temozolomide)

Brand name: Temonat

Active Ingeridents(Generic Name) : Temozolomide

Company Name: Natco

Package: 5 Capsules

Strength: 100mg

Indication:

It is used as a treatment of some brain cancers; as a second-line treatment for astrocytoma and a first-line treatment for glioblastoma multiforme.

Temonat (Temozolomide) is an antineoplastic agent. It works by stopping cancer cells from growing and reproducing.

Mechanism of action:

The therapeutic benefit of Temonat (Temozolomide) depends on its ability toalkylate/methylate DNA, which most often occurs at the N-7 or O-6 positions ofguanine residues. This methylation damages the DNA and triggers the death of tumor cells. However, some tumor cells are able to repair this type of DNA damage, and therefore diminish the therapeutic efficacy of Temonat (Temozolomide) , by expressing a protein O⁶-alkylguanine DNA alkyltransferase (AGT) encoded in humans by the O-6-methylguanine-DNA methyltransferase (MGMT) gene.In some tumors, epigenetic silencing of the MGMT gene prevents the synthesis of this enzyme, and as a consequence such tumors are more sensitive to killing by Temonat (Temozolomide) .Conversely, the presence of AGT protein in brain tumors predicts poor response to Temonat (Temozolomide) and these patients receive little benefit from chemotherapy with Temonat (Temozolomide) .

Dosage and Administration:

• This medication is given in a capsule form by mouth.
• Take on an empty stomach (1 hour before or 2 hours after meals or at bedtime) to reduce stomach upset.
• Do not open, crush, or chew capsules; swallow capsules whole with full 8 ounces of water.
• The frequency and the amount of this medication you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer you have. Your doctor will determine your dosage and schedule.

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Anxiety; back pain; breast pain; constipation; cough; diarrhea; dizziness; drowsiness; dry skin; hair loss; headache; joint pain; loss of appetite; mild stomach pain; mouth or tongue sores; muscle aches; nausea; taste changes; tiredness; trouble sleeping; vomiting; weakness; weight gain.

Precaution:

• Before starting Temonat (Temozolomide) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, or products containing aspirin unless your doctor specifically permits this.
• Do not receive any kind of immunization or vaccination without your doctor''s approval while taking Temonat (Temozolomide) .
• Let your health care provider know if you''ve had an allergic reaction to this drug or dacarbazine (DTIC) in the past, you may not be able to take temozolamide.

Store: Temonat (Temozolomide) is usually handled and stored by a health care provider. If you are using Temonat (Temozolomide) at home, store Temonat (Temozolomide) as directed by your pharmacist or health care provider. Keep Temonat (Temozolomide) out of the reach of children and away from pets.

Approx. Rs 1,400 / VialGet Latest Price

Bandrone (Ibandronic acid) 

Brand name: Bandrone 6mg injection

Active Ingeridents (Generic Name) : Ibandronic acid

Company Name: Natco

Package: Vial

Strength : 6mg

Indication:

It is used in the prevention and treatment of osteoporosis and metastasis-associated skeletal fractures in people with cancer. It may also be used to treat hypercalcemia (elevated blood calcium levels).

Also, Treating osteoporosis (weak bones) in women who are past menopause. It may also be used for other conditions as determined by your doctor. Ibandronate is a bisphosphonate. It works by slowing bone loss and allowing new bone to be formed.

Mechanism of action:

The action of Bandrone (Ibandronic acid)on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting farnesyl pyrophosphate (FPP) synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.

Dosage & Administration:

Use Bandrone (Ibandronic acid)as directed by your doctor. Check the label on the medicine for exact dosing instructions.

· Bandrone (Ibandronic acid)comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Bandrone (Ibandronic acid)refilled.

· Bandrone (Ibandronic acid) is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.

· Ask your health care provider any questions you may have about how to use Bandrone (Ibandronic acid).

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; headache; heartburn; mild arm, back, leg, muscle, or joint pain; mild flu-like symptoms (eg, mild fever, chills, tiredness, weakness, joint or muscle aches); nausea; pain, swelling, or redness at the injection site; stomach pain or upset.

Precaution:

Before taking Bandrone (Ibandronic acid), tell your doctor or pharmacist if you are allergic to it; or to other bisphosphonates; or if you have any other allergies.

Store: Bandrone (Ibandronic acid)is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets.

Additional Information:

Approx. Rs 8,750 / boxGet Latest Price

Temodal 100mg Capsule consists of the active substance Temozolomide. It is prescribed to treat adults with brain cancer. It is the standard drug used in combination with radiotherapy to treat patients with glioblastoma multiforme and anaplastic astrocytoma. Glioblastoma and anaplastic astrocytoma are the most common and aggressive brain cancers with low chances of survival. Anaplastic astrocytoma is treated with Temodal 100mg Capsule or radiotherapy after biopsy, whereas Glioblastoma multiforme is treated with a combination of radiotherapy and Temodal 100mg Capsule and then Temodal 100mg Capsule is continued as maintenance therapy.

Temodal 100mg uses:

• Concomitant and maintenance treatment along with radiotherapy for treatment of newly diagnosed glioblastoma multiforme.
• Treatment of refractory anaplastic astrocytoma in patients who experienced disease progression after being treated with nitrosurea and procarbazine.

How Temodal 100mg Capsule Works:

Temodal 100mg Capsule works by following a process called alkylation. After administration, Temodal temozolamide gets converted into its active form called metabolite 5-(3-methyltriazen-1-yl) imidazole-4-carboxamide (MTIC). This metabolite reacts with water to form methyl diazonium ions. The methyl group from methyl diazonium ions transfer into the DNA and breaks the DNA strands that results in cell cycle arrest and cell death.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Store the medicines in a locked cupboard, away from sight and reach of children. Do not store above 25??C. 

 How to use Temodal 100mg Capsule:

Use as directed by your physician. Your physician will prescribe an adequate dose according to your height and weight. Swallow the Capsule whole with a glass of water, on an empty stomach. Do not crush or chew the Capsule and avoid contact of the Capsule with your skin.

Safety Advice:

Pregnancy:

Temodal 100mg is harmful to the fetus. Inform your physician before taking Temodal 100mg Capsule if you are pregnant or think you might be pregnant.

Breastfeeding: 

Temodal 100mg Capsule passes through breast milk. Consult your physician for advice before breastfeeding.

Liver: 

Inform your physician before taking Temodal 100mg Capsule if you have liver problems.

Kidney:

Inform your physician before taking Temodal 100mg Capsule if you have kidney problems.

Driving:

Avoid driving or doing things that require concentration if you experience any side effects.

Allergies:

Inform your physician right away if you have allergic reactions to Temodal 100mg Capsule or its ingredients

Others:

• Consult your physician if you have blood clotting problems, low levels of RBC, WBC or platelets. Make sure that your physician monitors your WBC and platelet counts regularly.
• Inform your physician if you have a history of Hepatitis B infection.
• Temodal 100mg Capsule can cause birth defects. Exercise effective birth control measures during treatment with Temodal 100mg Capsule

• Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. The Temodal side effects are:

   

  Serious:

  • Secondary cancer like myelodysplastic syndrome and myeloid leukemia.
  • Severe Allergic reactions
  • Inflammation and fluid buildup in lungs

Approx. Rs 11,982 / PieceGet Latest Price

Approx. Rs 24,000 / StripGet Latest Price

Approx. Rs 2,450 / PackGet Latest Price

Bonimet (Ibandronic acid) 

Brand name: Bonimet

Active Ingeridents (Generic Name) : Ibandronic acid

Company Name: Intas

Package: Vial

Strength : 6mg

Indication:

It is used in the prevention and treatment of osteoporosis and metastasis-associated skeletal fractures in people with cancer. It may also be used to treat hypercalcemia (elevated blood calcium levels).

Also, Treating osteoporosis (weak bones) in women who are past menopause. It may also be used for other conditions as determined by your doctor. Ibandronate is a bisphosphonate. It works by slowing bone loss and allowing new bone to be formed.

Mechanism of action:

The action of Bonimet (Ibandronic acid)on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting farnesyl pyrophosphate (FPP) synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.

Dosage & Administration:

Use Bonimet (Ibandronic acid)as directed by your doctor. Check the label on the medicine for exact dosing instructions.

· Bonimet (Ibandronic acid)comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Bonimet (Ibandronic acid)refilled.

· Bonimet (Ibandronic acid) is given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.

· If you miss your scheduled dose of Bonimet (Ibandronic acid), contact your doctor to reschedule it as soon as possible. Do not receive your injection more often than once every 3 months.

Ask your health care provider any questions you may have about how to use Bonimet (Ibandronic acid).

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; headache; heartburn; mild arm, back, leg, muscle, or joint pain; mild flu-like symptoms (eg, mild fever, chills, tiredness, weakness, joint or muscle aches); nausea; pain, swelling, or redness at the injection site; stomach pain or upset.

Precaution:

Before taking Bonimet (Ibandronic acid), tell your doctor or pharmacist if you are allergic to it; or to other bisphosphonates; or if you have any other allergies.

Store: Bonimet (Ibandronic acid)is handled and stored by a health care provider. You will not store it at home. Keep all medicines out of the reach of children and away from pets..

Approx. Rs 35,600 / PieceGet Latest Price

Lynparza Olaparib uses

Olaparib is used in the treatment of ovarian cancer.

How olaparib works

Olaparib is an anticancer medication. It works by stopping Poly-ADP-ribose polymerase (PARP) from working. PARP is a protein that helps cancer cells to repair themselves and continue to survive.

Approx. Rs 25,500 / PackGet Latest Price

Faslodex (Fulvestrant)

Brand name: Faslodex

Active Ingeridents (Generic Name) :Fulvestrant)

Company Name: Astrazeneca

Package: One prefilled syringe containing 5ml or 250mg Faslodex (Fulvestrant)

Strength : 250mg/5ml

Indication:

Faslodex (Fulvestrant) is an anti-estrogen medication. It works by blocking the actions of estrogen in the body. Certain types of breast cancer use estrogen to grow and multiply in the body.

Faslodex (Fulvestrant) is used to treat a certain type of hormone-related breast cancer in postmenopausal women, when the cancer has spread to other parts of the body after treatment with anti-estrogen medication.

Faslodex (Fulvestrant) is also used together with a medicine called palbociclib, to treat certain hormone-related breast cancer that has progressed or spread after treatment with hormonal therapy.

Mechanism of action:

Faslodex (Fulvestrant) competitively and reversibly binds to estrogen receptors present in cancer cells and achieves its anti-estrogen effects through two separate mechanisms. First, Faslodex (Fulvestrant) binds to the receptors and downregulates them so that estrogen is no longer able to bind to these receptors. Second, Faslodex (Fulvestrant) degrades the estrogen receptors to which it is bound. Both of these mechanisms inhibit the growth of tamoxifen-resistant as well as estrogen-sensitive human breast cancer cell lines. 

Dosage & Administration:

As an injection into the muscle (intramuscular, IM), Faslodex (Fulvestrant) is usually given as a once a month injection. Your doctor will determine any variations to this dosing or schedule.

Side effects:

Get emergency medical help if you have signs of an allergic reaction to Faslodex (Fulvestrant): hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common Faslodex (Fulvestrant) side effects may include:

Headache, bone pain, joint pain, muscle pain, nausea, vomiting, loss of appetite, constipation; weakness, feeling tired; cough, trouble breathing; abnormal liver function tests; hot flashes; or pain where the medicine was injected.

Precaution:

• Before starting Faslodex (Fulvestrant) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take , or products containing unless your doctor specifically permits this.
• Let your health care professional know if you have ever had a blood clot that required medical treatment.
• Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (Faslodex (Fulvestrant) may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus).

Store: Faslodex (Fulvestrant) is handled and stored by a health care provider. Keep all medicines out of the reach of children and away from pets.

Approx. Rs 370 / PIECEGet Latest Price

Daunorubitec (Daunorubicin)

Brand name: Daunorubitec

Active Ingeridents (Generic Name) : Daunorubicin

Company Name: United Biotech

Package: Vial

Strength : 20mg

Indication:

It is used in the treatment of Acute Myelogenous Leukemia (AML) and Acute Lymphoblastic Leukemia (ALL). It may be used in combination with other medicines. It may also be used for other conditions as determined by your doctor.

Mechanism of action:

Daunorubitec (Daunorubicin) has antimitotic and cytotoxic activity through a number of proposed mechanisms of action: Daunorubitec (Daunorubicin) forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Dosage & Administration:

• Daunorubitec (Daunorubicin) is given by intravenous injection (IV). The syringe needle is placed directly into the tubing of a freely flowing IV solution into a vein or central line and the drug is given over several minutes.
• Daunorubitec (Daunorubicin) is a vesicant. A vesicant is a chemical that causes extensive tissue damage and blistering if it escapes from the vein. The nurse or doctor who gives this drug must be carefully trained. If you notice redness or swelling at the IV site while you are receiving Daunorubitec (Daunorubicin) , alert your health care professional immediately.
• The amount of Daunorubitec (Daunorubicin) you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer you have. Your doctor will determine your dose and schedule.

Side effects:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; hair loss; loss of appetite; mouth pain; nausea; sore throat; stomach pain; tiredness; weakness.

Precaution:

• Before starting Daunorubitec (Daunorubicin) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take , products containing unless your doctor specifically permits this.
• Do not receive any kind of immunization or vaccination without your doctor's approval while taking Daunorubitec (Daunorubicin) .
• You may be more sensitive to sunlight, take extra care to avoid sun exposure.
• People with congestive heart failure, those who have already had high doses of this drug or a similar drug, and those with permanent problems with blood counts (bone marrow suppression) cannot receive this drug.

Store: Daunorubitec (Daunorubicin) is usually handled and stored by a health care provider. If you are using Daunorubitec (Daunorubicin) at home, store Daunorubitec (Daunorubicin) as directed by your pharmacist or health care provider. Keep Daunorubitec (Daunorubicin) out of the reach of children and away from pets.

Approx. Rs 18,000 / PackGet Latest Price

Fulvenat (Fulvestrant)

Brand name: Fulvenat 

Active Ingeridents (Generic Name) : Fulvestrant

Company Name: Natco 

Package: One prefilled syringe containing 5ml or 250mg Fulvenat (Fulvestrant)

Strength : 250mg/5ml

Indication:

Fulvenat (Fulvestrant) is an anti-estrogen medication. It works by blocking the actions of estrogen in the body. Certain types of breast cancer use estrogen to grow and multiply in the body.

Fulvenat (Fulvestrant) is used to treat a certain type of hormone-related breast cancer in postmenopausal women, when the cancer has spread to other parts of the body after treatment with anti-estrogen medication.

Fulvenat (Fulvestrant) is also used together with a medicine called palbociclib, to treat certain hormone-related breast cancer that has progressed or spread after treatment with hormonal therapy.

Mechanism of action:

Fulvenat (Fulvestrant) competitively and reversibly binds to estrogen receptors present in cancer cells and achieves its anti-estrogen effects through two separate mechanisms. First, Fulvenat (Fulvestrant) binds to the receptors and downregulates them so that estrogen is no longer able to bind to these receptors. Second, Fulvenat (Fulvestrant) degrades the estrogen receptors to which it is bound. Both of these mechanisms inhibit the growth of tamoxifen-resistant as well as estrogen-sensitive human breast cancer cell lines. 

Dosage & Administration:

As an injection into the muscle (intramuscular, IM), Fulvenat (Fulvestrant) is usually given as a once a month injection. Your doctor will determine any variations to this dosing or schedule.

Side effects:

Get emergency medical help if you have signs of an allergic reaction to Fulvenat (Fulvestrant): hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Common Fulvenat (Fulvestrant) side effects may include:

Headache, bone pain, joint pain, muscle pain, nausea, vomiting, loss of appetite, constipation; weakness, feeling tired; cough, trouble breathing; abnormal liver function tests; hot flashes; or pain where the medicine was injected.

Precaution:

• Before starting Fulvenat (Fulvestrant) treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take , or products containing unless your doctor specifically permits this.
• Let your health care professional know if you have ever had a blood clot that required medical treatment.
• Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (Fulvenat (Fulvestrant) may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus).

Store: Fulvenat (Fulvestrant) is handled and stored by a health care provider. Keep all medicines out of the reach of children and away from pets.