Hepatitis Medicine

Approx. Rs 3,000 / BottleGet Latest Price

Dalsiclear (Daclatasvir )

Brand name: Dalsiclear

Active Ingeridents(Generic Name) : Daclatasvir

Company Name: Abbott

Package: 28 Tablets/Bottle

Strength : 60 mg

Indication:

Daclatasvir is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Daclatasvir should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin). These medications together reduce the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.

Daclatasvir 60mg is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver.Daclatasvir 60mg tablet should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin). These medications together reduce the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.Daclatasvir Price, Daclatasvir Cost.Daclatasvir Dose.

Mechanism of action:

The dimeric symmetry of these compounds suggests that they act on a dimer of NS5A, which is also consistent with the presence of dimers in crystals of NS5A domain 1 from genotype 1b. Genotype 1a HCV is less potently affected by these compounds and resistance mutations have a greater effect than in the 1b genotypes. We have obtained crystals of domain 1 of the important 1a NS5A homologue and intriguingly, our X-ray crystal structure reveals two new dimeric forms of this domain. Furthermore, the high solvent content (75%) makes it ideal for ligand-soaking. Daclatasvir (DCV) shows twofold symmetry suggesting NS5A dimers may be of physiological importance and serve as potential binding sites for DCV. These dimers also allow for new conformations of a NS5A expansive network which could explain its operation on the membranous web. Additionally, sulfates bound in the crystal structure may provide evidence for the previously proposed RNA binding groove, or explain regulation of NS5A domain 2 and 3 function and phosphorylation. 

Dosage and Administration:

Take daclatasvir exactly as your healthcare provider tells you to.

· Do not change your dose unless your healthcare provider tells you to.

· Do not stop taking daclatasvir without first talking with your healthcare provider.

· Take daclatasvir 1 time each day with or without food.

The recommended usage of daclatasvir to treat chronic hepatitis C virus is 60 mg taken orally once daily with or without food in combination with sofosbuvir. The recommended treatment duration is 12 weeks.

Side effects:

Tiredness, headache, nausea, or diarrhea may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Precaution: Before taking daclatasvir, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Store:. Daclatasvir room temperature away from moisture and heat. 

Approx. Rs 6,000 / BottleGet Latest Price

Resof

• Brand name: Resof
• Active Ingeridents(Generic Name) : Sofosbuvir
• Company Name: Dr.Reddy’s
• Package: 28 Tablets/bottle
• Strength : 400mg

Indication:It is used for the treatment of hepatitis Cvirus (HCV) infection. Compared to previous treatments, sofosbuvir-based regimens provide a higher cure rate, fewer side effects, and a two- to four-fold reduced duration of therapy. Sofosbuvir allows most patients to be treated successfully without the use of peginterferon,an injectable drug with severe side effects^. that is a key component of older drug combinations for the treatment of HCV.

Sofosbuvir is used for the treatment of chronic hepatitis C, genotypes 1, 2, 3, and 4, in combination with pegylated interferon and ribavirin, or with ribavirin alone. It is also used in combination with the viral NS5a inhibitor ledipasvir in an interferon-free combination for the treatment of genotype 1 hepatitis C infection. Sofosbuvir is also used in HCV patients with an HIV coinfection. The treatment is based on a number of clinical trials, for example the ELECTRON trial which showed that a dual interferon-free regimen of sofosbuvir plus ribavirin produced a 24-week post-treatment sustained virological response (SVR24) rate of 100% for previously untreated patients with HCV genotypes 2 or 3.

Sofosbuvir 400mg tablets  is used with other antiviral medications (such as ribavirin, peginterferon, daclatasvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. It works by reducing the amount of hepatitis C virus in your body, which may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. sofosbuvir cost, Sofosbuvir price , Sofosbuvir Buy online. 

Mechanism of action:Sofosbuvir contains oral nucleotide analog inhibitor of the hepatitis C virus (HCV) polymerase. The drug is a direct-acting antiviral agent and interferes straight with the HCV lifecycle, restraining the viral replication. It can be incorporated into HCV RNA by the NS5B polymerase and acts as a chain terminator. The drug is available for oral use in the form of 400mg tablets.

Dosage and Administration:

The recommended daily dose of Sofosbuvir is 400mg tablet to be taken once daily with or without food. Sofosbuvir should be used in combination with Ribavirin or in combination with Pegylated Interferon and Ribavirin for the treatment of CHC (Chronic Hepatitis C) in adults. It is highly advisable to administer the drug under strict medical supervision and advice.

Side effects:

Adverse events associated with the use of Sofosbuvir in combination with Ribavirin may include, but are not limited to, the following

o Fatigue , headache Adverse events associated with the use of Sofosbuvir in combination with Peginterferon Alfa and Ribavirin may include, but are not limited to, the following:

o fatigue,headache, nausea, insomnia, anemia

Precaution: Safety and efficacy have not been established in patients younger than 18 years. Consult WARNINGS section for additional precautions.

Store: Store at 25°C in a dry place.

Approx. Rs 3,380 / BottleGet Latest Price

X-Vir (Entecavir) is used as an antiviral treatment for patients suffering from a chronic hepatitis B infection. It is classified as a nucleoside analog, and it works by stopping the spread of the virus. Because it can inhibit an enzyme called viral DNA polymerase, it is able to prevent the spread and proliferation of the virus. This can help to reduce the overall amount of the virus present in the body, while also helping to lessen damage to the liver.

X-Vir (Entecavir) is administered orally. It comes as either 0.5mg or 1mg strength tablets. Your physician will be responsible for deciding the right dosage. Adults treating hepatitis B who are deemed to be nucleoside therapy naive may be directed to take 0.5mg once per day. However, some patients may be directed to take 1mg per day (usually in cases of mutations of the virus that are resistance to lamivudine or otherwise difficult to treat). Patients must strictly comply with the instructions given by their physician.

The use of X-Vir (Entecavir) could cause side effects. Tell the physician providing medical care if this happens. Some possible examples are given here:

• Diarrhea
• Headaches
• Digestive discomfort
• Sleepy or fatigued feeling
• Nausea, possibly resulting in vomiting

Although the majority of side effects caused by this medicine are less serious in nature, there is a possibility that some patients will be affected by reactions which are significantly more serious. You must attend the hospital or see your physician straight away if you are affected by coldness, persistent vomiting, feeling weak or any other serious side effects not mentioned here.

Serious conditions including hepatomegaly and lactic acidosis are known to have occurred in some patients treated with X-Vir (Entecavir) for their condition. Discuss this with your physician before starting therapy.

This medication will not cure the infection, and you will need continuous medical treatment in order to manage your condition.

Approx. Rs 7,999 / BottleGet Latest Price

Resof 400mg tablets is used with other antiviral medications (such as ribavirin, peginterferon, daclatasvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. It works by reducing the amount of hepatitis C virus in your body, which may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. sofosbuvir cost, Sofosbuvir price , Sofosbuvir Buy online.


Hepcfix:

Hepcfix 60mg is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver.Daclatasvir 60mg tablet should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin). These medications together reduce the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer.Daclatasvir Price, Daclatasvir Cost.Daclatasvir Dose.

Additional Information:

Approx. Rs 15,000 / BottleGet Latest Price

Uses of Velpaclear Tablet

Velpaclear Tablet is used in the treatment of chronic hepatitis C virus (HCV) infection.

How Velpaclear Tablet works

Velpaclear Tablet is a combination of two antiviral medicines: Sofosbuvir and Velpatasvir. They work by lowering the amount of hepatitis C virus in the body and removing the virus from the blood over a period of time.

How to use Velpaclear Tablet

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Velpaclear Tablet may be taken with or without food, but it is better to take it at a fixed time.

Approx. Rs 1,350 / PieceGet Latest Price

Entavir (Entecavir)

Brand name: Entavir

Active Ingeridents(Generic Name) : Entecavir

Company Name: Cipla

Package: 10 Tablets

Strength : 1mg

Indication: Entecavir is used to treat long-term hepatitis B infection. Hepatitis B is an infection of the liver caused by the hepatitis B virus. Long-term infection can cause liver damage, rarely liver cancer, and liver failure. Entecavir helps to decrease the amount of hepatitisB virus in your body. It is unknown if this medication lowers your chance of gettingliver cancer or liver damage. Entecavir is an antiviral that belongs to a class of drugs known as hepatitis B virus nucleoside reverse transcriptase inhibitors.

Mechanism of action:

Entecavir is mainly used to treat chronic hepatitis B infection in adults and children 2 years and older with active viral replication and evidence of active disease.It is also used to prevent HBV reinfection after liver transplant and to treat HIV patients infected with HBV. Entecavir is weakly active against HIV, however it is not recommended for use in HIV-HBV co-infected patients without a fully suppressive anti-HIV regimen as it may select for resistance to lamivudine and emtricitabine in HIV.

Dosage and Administration:

· Take entecavir on an empty stomach, at least 2 hours after a meal and at least 2 hours before the next meal.

· Entecavir works best if it is taken at the same time each day.

· Continue to take entecavir even if you feel well. Do not miss any doses.

· If you miss a dose of entecavir, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Side effects:

Dizziness; headache; nausea; tiredness.

Precaution:

An overdose entecavir Unlikely to threaten life, call an emergency room or a poison control center for advice if you suspect that a very large dose of entecavir has been ingested.

There are no restrictions on food, beverages, or activities while taking entecavir otherwise directed by your physician.

Store:

Store entecavir in the original carton at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep entecavir out of the reach of children and away from pets.

Approx. Rs 2,097 / BottleGet Latest Price

X-vir (Entecavir)

• Brand name: X-vir 
• Active Ingeridents(Generic Name) : Entecavir 
• Company Name: Natco
• Package: 30 Tablets
• Strength : 0.5mg

Indication: Entecavir is used to treat long-term hepatitis B infection. Hepatitis B is an infection of the liver caused by the hepatitis B virus. Long-term infection can cause liver damage, rarely liver cancer, and liver failure. Entecavir helps to decrease the amount of hepatitisB virus in your body. It is unknown if this medication lowers your chance of gettingliver cancer or liver damage. Entecavir is an antiviral that belongs to a class of drugs known as hepatitis B virus nucleoside reverse transcriptase inhibitors.

Mechanism of action:

Entecavir is mainly used to treat chronic hepatitis B infection in adults and children 2 years and older with active viral replication and evidence of active disease.It is also used to prevent HBV reinfection after liver transplant and to treat HIV patients infected with HBV. Entecavir is weakly active against HIV, however it is not recommended for use in HIV-HBV co-infected patients without a fully suppressive anti-HIV regimen as it may select for resistance to lamivudine and emtricitabine in HIV. 

Dosage and Administration:

· Take entecavir on an empty stomach, at least 2 hours after a meal and at least 2 hours before the next meal.

· Entecavir works best if it is taken at the same time each day.

· Continue to take entecavir even if you feel well. Do not miss any doses.

· If you miss a dose of entecavir, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Side effects:

Dizziness; headache; nausea; tiredness. 

Precaution:

An overdose entecavir Unlikely to threaten life, call an emergency room or a poison control center for advice if you suspect that a very large dose of entecavir has been ingested.

There are no restrictions on food, beverages, or activities while taking entecavir otherwise directed by your physician. 

Store:

Store entecavir in the original carton at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep entecavir out of the reach of children and away from pets.

Approx. Rs 8,500 / BottleGet Latest Price

Velakastmanufactured by Natco and marketedAprazer is the combination Velpatasvir 100mg & Sofosbuvir 400mg and is used to treatment of chronic (long-lasting) hepatitis C, a viral infection of the liver(HCV). Velakast is also used with another antiviral medication (ribavirin). Velakast work by reducing the amount of hepatitis C virus in your body, which helps your immune system fight the infection and may help your liver recover.

Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer which will be cure by Velakast

Velakast -Sofosbuvir 400 mg & velpatasvir 100 mg is used alone or with ribavirin to treat chronic hepatitis C. Velakast -Sofosbuviris in a class of antiviral medications called nucleotide hepatitis C virus (HCV) NS5B polymerase inhibitors. Velakast -Velpatasviris in a class of antiviral medications called HCV NS5A replication complex inhibitors.

The Velakast combination of sofosbuvir and Velpatasvir works by stopping the virus that causes hepatitis C from spreading inside the body

Additional Information: